Distinct Neutrophil Populations in the Spleen During PICS

by Satarupa Sengupta, Charles C. Caldwell, Charles C. Caldwell, Vanessa Nomellini, Vanessa Nomellini
Published 2020-05-01

Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression.

by Nadine Beckmann, Amanda M Pugh, Charles C Caldwell
Published 2018-01-01

Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling

by Nadine Beckmann, Franziska Huber, Marc Hanschen, Barbara St. Pierre Schneider, Vanessa Nomellini, Vanessa Nomellini, Charles C. Caldwell, Charles C. Caldwell
Published 2020-05-01

Potential Targets to Mitigate Trauma- or Sepsis-Induced Immune Suppression

by Christian B. Bergmann, Nadine Beckmann, Christen E. Salyer, Marc Hanschen, Marc Hanschen, Peter A. Crisologo, Charles C. Caldwell, Charles C. Caldwell
Published 2021-02-01

Enigmatic role of coagulopathy among sepsis survivors: a review of coagulation abnormalities and their possible link to chronic critical illness

by Vanessa Nomellini, Nadine Beckmann, Leah K Winer, Christen Salyer, Charles C Caldwell
Published 2020-12-01

Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Platelet Dysfunction

by Friederike Hefele, Friederike Hefele, Alexander Ditsch, Niels Krysiak, Niels Krysiak, Charles C. Caldwell, Charles C. Caldwell, Peter Biberthaler, Martijn van Griensven, Stefan Huber-Wagner, Marc Hanschen, Marc Hanschen
Published 2019-10-01

A Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome

by Amanda M. Pugh, Nicholas J. Auteri, Holly S. Goetzman, Charles C. Caldwell, Vanessa Nomellini
Published 2017-08-01

The effect of ghrelin upon the early immune response in lean and obese mice during sepsis.

by Daniel Siegl, Emily F Midura, Thorsten Annecke, Peter Conzen, Charles C Caldwell, Johannes Tschoep
Published 2015-01-01

Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides

by Jie Ma, Erich Gulbins, Michael J. Edwards, Charles C. Caldwell, Martin Fraunholz, Katrin Anne Becker
Published 2017-10-01

Therapeutic Inhaled Sphingosine for Treating Lung Infection in a Mouse Model of Critical Illness

by Nadine Beckmann, Amanda M. Pugh, Nicholas J. Auteri, Michael J. Edwards, Erich Gulbins, Charles C. Caldwell
Published 2020-10-01

TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function

by Christian B. Bergmann, Bruce D. Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C. Caldwell, Dorothy M. Supp
Published 2021-08-01

Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage

by Richard S. Hoehn, Peter L. Jernigan, Alex L. Chang, Michael J. Edwards, Charles C. Caldwell, Erich Gulbins, Timothy A. Pritts
Published 2016-06-01

Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis

by Brent T. Xia, Nadine Beckmann, Leah K. Winer, Amanda M. Pugh, Timothy A. Pritts, Vanessa Nomellini, Erich Gulbins, Charles C. Caldwell
Published 2019-03-01

Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine

by Katrin Anne Becker, Xiang Li, Aaron Seitz, Joerg Steinmann, Anne Koch, Edward Schuchman, Markus Kamler, Michael J. Edwards, Charles C.  Caldwell, Erich Gulbins
Published 2017-10-01

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

by Manfred Thiel, Charles C Caldwell, Simone Kreth, Satoshi Kuboki, P Chen, Patrick Smith, Akio Ohta, Alex B Lentsch, Dmitry Lukashev, Michail V Sitkovsky
Published 2007-09-01

Characterization of microparticles after hepatic ischemia-reperfusion injury.

by Christopher M Freeman, Ralph C Quillin, Gregory C Wilson, Hiroyuki Nojima, Bobby L Johnson, Jeffrey M Sutton, Rebecca M Schuster, John Blanchard, Michael J Edwards, Charles C Caldwell, Alex B Lentsch
Published 2014-01-01

In Vitro–Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019

by Monty B. Mazer, MD, Ethan Davitt, , BS, Isaiah R. Turnbull, MD, PhD, Charles C. Caldwell, PhD, Scott C. Brakenridge, MD, Kenneth E. Remy, MD, MHSc, MSCI, Richard S. Hotchkiss, MD
Published 2021-04-01

Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

by Kenneth E. Remy, Monty Mazer, David A. Striker, Ali H. Ellebedy, Andrew H. Walton, Jacqueline Unsinger, Teresa M. Blood, Philip A. Mudd, Daehan J. Yi, Daniel A. Mannion, Dale F. Osborne, R. Scott Martin, Nitin J. Anand, James P. Bosanquet, Jane Blood, Anne M. Drewry, Charles C. Caldwell, Isaiah R. Turnbull, Scott C. Brakenridge, Lyle L. Moldwawer, Richard S. Hotchkiss
Published 2021-02-01

Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report

by Monty B. Mazer, MD, Isaiah R. Turnbull, MD, PhD, Sydney Miles, BS, Teresa M. Blood, BS, Brooke Sadler, PhD, Annie Hess, MD, Mitchell D. Botney, MD, Robert S. Martin, MD, James P. Bosanquet, MD, David A. Striker, MD, Nitin S. Anand, MD, Michel Morre, DVM, MSc, Charles C. Caldwell, PhD, Scott C. Brakenridge, MD, MSCS, Lyle L. Moldawer, PhD, Jorge A. Di Paola, MD, Richard S. Hotchkiss, MD, Kenneth E. Remy, MD, MHSc, MSCI
Published 2021-07-01