Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells.

by Shalini Sethumadhavan, Murillo Silva, Phaethon Philbrook, Thao Nguyen, Stephen M Hatfield, Akio Ohta, Michail V Sitkovsky
Published 2017-01-01

Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury.

by Manfred Thiel, Alexander Chouker, Akio Ohta, Edward Jackson, Charles Caldwell, Patrick Smith, Dmitry Lukashev, Iris Bittmann, Michail V Sitkovsky
Published 2005-06-01

Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

by Murillo Silva, Thao H. Nguyen, Phaethon Philbrook, Matthew Chu, Olivia Sears, Stephen Hatfield, Robert K. Abbott, Garnett Kelsoe, Michail V. Sitkovsky
Published 2017-12-01

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

by Manfred Thiel, Charles C Caldwell, Simone Kreth, Satoshi Kuboki, P Chen, Patrick Smith, Akio Ohta, Alex B Lentsch, Dmitry Lukashev, Michail V Sitkovsky
Published 2007-09-01

Toll-like Receptor 3 Regulates Angiogenesis and Apoptosis in Prostate Cancer Cell Lines through Hypoxia-Inducible Factor 1α

by Alessio Paone, Roberta Galli, Chiara Gabellini, Dmitriy Lukashev, Donatella Starace, Agnes Gorlach, Paola De Cesaris, Elio Ziparo, Donatella Del Bufalo, Michail V. Sitkovsky, Antonio Filippini, Anna Riccioli
Published 2010-07-01