Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts

by Xueke Shi, Christian D. Young, Hongmei Zhou, Xiao-Jing Wang
Published 2020-12-01

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.

by Meghan M Morrison, Christian D Young, Shan Wang, Tammy Sobolik, Violeta M Sanchez, Donna J Hicks, Rebecca S Cook, Dana M Brantley-Sieders
Published 2015-07-01

Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis

by Meghan Morrison Joly, Michelle M. Williams, Donna J. Hicks, Bayley Jones, Violeta Sanchez, Christian D. Young, Dos D. Sarbassov, William J. Muller, Dana Brantley-Sieders, Rebecca S. Cook
Published 2017-06-01

Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo.

by Christian D Young, Andrew S Lewis, Michael C Rudolph, Marisa D Ruehle, Matthew R Jackman, Ui J Yun, Olesya Ilkun, Renata Pereira, E Dale Abel, Steven M Anderson
Published 2011-01-01

Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma

by Alexander A. Strait, Rachel A. Woolaver, Spencer C. Hall, Christian D. Young, Sana D. Karam, Antonio Jimeno, Yan Lan, David Raben, Jing H. Wang, Xiao-Jing Wang
Published 2021-08-01

Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15⁺ Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma

by Samantha M. Y. Chen, Bian Li, Andrew G. Nicklawsky, Alexandra L. Krinsky, Tonya Brunetti, Rachel A. Woolaver, Xiaoguang Wang, Zhangguo Chen, Christian D. Young, Dexiang Gao, Xiao-Jing Wang, Jing H. Wang
Published 2020-09-01

Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche

by Xueke Shi, Xueke Shi, Jingjing Luo, Jingjing Luo, Kelsey J. Weigel, Spencer C. Hall, Danfeng Du, Fanglong Wu, Fanglong Wu, Michael C. Rudolph, Hongmei Zhou, Christian D. Young, Xiao-Jing Wang, Xiao-Jing Wang
Published 2021-08-01