Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model)

by Rebecca Broeckel, Nicole Haese, Ilhem Messaoudi, Daniel N. Streblow
Published 2015-09-01

Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and Latency

by Katie Caviness, Farah Bughio, Lindsey B. Crawford, Daniel N. Streblow, Jay A. Nelson, Patrizia Caposio, Felicia Goodrum
Published 2016-03-01

Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease

by Rebecca M. Broeckel, Nicole Haese, Takeshi Ando, Igor Dmitriev, Craig N. Kreklywich, John Powers, Michael Denton, Patricia Smith, Thomas E. Morrison, Mark Heise, Mark Heise, Victor DeFilippis, Ilhem Messaoudi, David T. Curiel, Daniel N. Streblow, Daniel N. Streblow
Published 2019-10-01

Human Cytomegalovirus Infection Suppresses CD34⁺ Progenitor Cell Engraftment in Humanized Mice

by Lindsey B. Crawford, Rebecca Tempel, Daniel N. Streblow, Andrew D. Yurochko, Felicia D. Goodrum, Jay A. Nelson, Patrizia Caposio
Published 2020-04-01

Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice

by Lindsey B. Crawford, Rebecca Tempel, Daniel N. Streblow, Craig Kreklywich, Patricia Smith, Louis J. Picker, Jay A. Nelson, Patrizia Caposio
Published 2017-04-01

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AI...

by Sara Botto, Jinu Abraham, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Igor Landais, Daniel N. Streblow, Klaus J. Fruh, Victor R. DeFilippis
Published 2019-02-01

Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity.

by Ilhem Messaoudi, Jennifer Vomaske, Thomas Totonchy, Craig N Kreklywich, Kristen Haberthur, Laura Springgay, James D Brien, Michael S Diamond, Victor R Defilippis, Daniel N Streblow
Published 2013-01-01

The Differentiation of Human Cytomegalovirus Infected-Monocytes Is Required for Viral Replication

by Chan-Ki Min, Akhalesh K. Shakya, Byeong-Jae Lee, Daniel N. Streblow, Patrizia Caposio, Andrew D. Yurochko, Andrew D. Yurochko, Andrew D. Yurochko, Andrew D. Yurochko
Published 2020-07-01

Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.

by Sixue Zhang, Atefeh Garzan, Nicole Haese, Robert Bostwick, Yohanka Martinez-Gzegozewska, Lynn Rasmussen, Daniel N Streblow, Mark T Haise, Ashish K Pathak, Corinne E Augelli-Szafran, Mousheng Wu
Published 2021-01-01

Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34+ Hematopoietic Progenitor Cells and Humanized NSG Mice

by Lindsey B. Crawford, Patrizia Caposio, Craig Kreklywich, Andrew H. Pham, Meaghan H. Hancock, Taylor A. Jones, Patricia P. Smith, Andrew D. Yurochko, Jay A. Nelson, Daniel N. Streblow
Published 2019-08-01

Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility.

by Jennifer Vomaske, Ryan M Melnychuk, Patricia P Smith, Joshua Powell, Laurel Hall, Victor DeFilippis, Klaus Früh, Martine Smit, David D Schlaepfer, Jay A Nelson, Daniel N Streblow
Published 2009-02-01

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.

by Jennifer L Uhrlaub, Vesna Pulko, Victor R DeFilippis, Rebecca Broeckel, Daniel N Streblow, Gary D Coleman, Byung S Park, John F Lindo, Ivan Vickers, Joshua J Anzinger, Janko Nikolich-Žugich
Published 2016-10-01

A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection.

by Mahadevaiah Umashankar, Alex Petrucelli, Louis Cicchini, Patrizia Caposio, Craig N Kreklywich, Michael Rak, Farah Bughio, Devorah C Goldman, Kimberly L Hamlin, Jay A Nelson, William H Fleming, Daniel N Streblow, Felicia Goodrum
Published 2011-12-01

Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses.

by John M Powers, Nicole N Haese, Michael Denton, Takeshi Ando, Craig Kreklywich, Kiley Bonin, Cassilyn E Streblow, Nicholas Kreklywich, Patricia Smith, Rebecca Broeckel, Victor DeFilippis, Thomas E Morrison, Mark T Heise, Daniel N Streblow
Published 2021-04-01

Rat Cytomegalovirus Virion-Associated Proteins R131 and R129 Are Necessary for Infection of Macrophages and Dendritic Cells

by Iris K. A. Jones, Nicole N. Haese, Philippe Gatault, Zachary J. Streblow, Takeshi F. Andoh, Michael Denton, Cassilyn E. Streblow, Kiley Bonin, Craig N. Kreklywich, Jennifer M. Burg, Susan L. Orloff, Daniel N. Streblow
Published 2020-11-01

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.

by Tina M Sali, Kara M Pryke, Jinu Abraham, Andrew Liu, Iris Archer, Rebecca Broeckel, Julia A Staverosky, Jessica L Smith, Ahmed Al-Shammari, Lisi Amsler, Kayla Sheridan, Aaron Nilsen, Daniel N Streblow, Victor R DeFilippis
Published 2015-12-01

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

by Maria Pelliccia, Patrizia Andreozzi, Jayson Paulose, Marco D’Alicarnasso, Valeria Cagno, Manuela Donalisio, Andrea Civra, Rebecca M. Broeckel, Nicole Haese, Paulo Jacob Silva, Randy P. Carney, Varpu Marjomäki, Daniel N. Streblow, David Lembo, Francesco Stellacci, Vincenzo Vitelli, Silke Krol
Published 2016-11-01

Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells

by Byeong-Jae Lee, Byeong-Jae Lee, Byeong-Jae Lee, Chan-Ki Min, Chan-Ki Min, Chan-Ki Min, Meaghan Hancock, Daniel N. Streblow, Patrizia Caposio, Felicia D. Goodrum, Andrew D. Yurochko, Andrew D. Yurochko, Andrew D. Yurochko, Andrew D. Yurochko
Published 2021-05-01

Cytomegalovirus Infection of the Rat Developing Brain In Utero Prominently Targets Immune Cells and Promotes Early Microglial Activation.

by Robin Cloarec, Sylvian Bauer, Hervé Luche, Emmanuelle Buhler, Emilie Pallesi-Pocachard, Manal Salmi, Sandra Courtens, Annick Massacrier, Pierre Grenot, Natacha Teissier, Françoise Watrin, Fabienne Schaller, Homa Adle-Biassette, Pierre Gressens, Marie Malissen, Thomas Stamminger, Daniel N Streblow, Nadine Bruneau, Pierre Szepetowski
Published 2016-01-01

A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

by Kara M. Pryke, Jinu Abraham, Tina M. Sali, Bryan J. Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason Baird, Michael Gough, Marita Chakhtoura, Elias K. Haddad, Ilsa T. Kirby, Aaron Nilsen, Daniel N. Streblow, Alec J. Hirsch, Jessica L. Smith, Victor R. DeFilippis, Terence S. Dermody
Published 2017-05-01