Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy

by Valdenizia R. Silva, Sara P. Neves, Luciano de S. Santos, Rosane B. Dias, Daniel P. Bezerra
Published 2020-11-01

Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity

by Thayane M. Queiroz, Erika V.M. Orozco, Valdenizia R. Silva, Luciano S. Santos, Milena B.P. Soares, Daniel P. Bezerra, André L.M. Porto
Published 2019-09-01

Design, Antileishmanial Activity, and QSAR Studies of a Series of Piplartine Analogues

by Flávio R. Nóbrega, Larisse V. Silva, Carlos da Silva M. Bezerra Filho, Tamires C. Lima, Yunierkis P. Castillo, Daniel P. Bezerra, Tatjana K. Souza Lima, Damião P. de Sousa
Published 2019-01-01

Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry

by Daniel P. Bezerra, Cláudia Pessoa, Manoel O. Moraes, Letícia V. Costa-Lotufo, Dayana Rubio Gouvea, Valquíria A. Polisel Jabor, Norberto Peporine Lopes, Keyller Bastos Borges, Mary Anne S. Lima, Edilberto R. Silveira
Published 2012-01-01

A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human ac...

by Maiara de S. Oliveira, Marília I.F. Barbosa, Thiago Belarmino de Souza, Diogo R.M. Moreira, Felipe Terra Martins, Wilmer Villarreal, Rafael P. Machado, Antônio Carlos Doriguetto, Milena B.P. Soares, Daniel P. Bezerra
Published 2019-01-01

Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Mo...

by Ingrid R. S. Baliza, Suellen L. R. Silva, Luciano de S. Santos, João H. Araujo Neto, Rosane B. Dias, Caroline B. S. Sales, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Alzir A. Batista, Daniel P. Bezerra
Published 2019-07-01

Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities

by TÁSSIA L.A. DOS SANTOS, RAPHAEL F. QUEIROZ, ALEXANDRA C.H.F. SAWAYA, BEGOÑA GIMENEZ-CASSINA LOPEZ, MILENA B.P. SOARES, DANIEL P. BEZERRA, ANA CAROLINA B.C. RODRIGUES, VANDERLÚCIA F. DE PAULA, ANA MARIA WALDSCHMIDT

Benzylated Dihydroflavones and Isoquinoline-Derived Alkaloids from the Bark of <i>Diclinanona calycina</i> (Annonaceae) and Their Cytotoxicities

by Emmanoel V. Costa, Liviane do N. Soares, Jamal da Silva Chaar, Valdenizia R. Silva, Luciano de S. Santos, Hector H. F. Koolen, Felipe M. A. da Silva, Josean F. Tavares, Gokhan Zengin, Milena B. P. Soares, Daniel P. Bezerra
Published 2021-06-01

Diversity of the diterpenes in the leaves of Xylopia laevigata (Annonaceae) and their cytotoxicities

by Emmanoel V. Costa, Marília F. C. Sampaio, Leociley R. A. Menezes, Lívia M. Dutra, Cinara O. S. Costa, Maria Lúcia B. Pinheiro, Felipe M. A. da Silva, Milena B. P. Soares, Daniel P. Bezerra, Andersson Barison, Hector H. F. Koolen

Ruthenium Complexes Containing Heterocyclic Thioamidates Trigger Caspase-Mediated Apoptosis Through MAPK Signaling in Human Hepatocellular Carcinoma Cells

by Sara P. Neves, Nanashara C. de Carvalho, Monize M. da Silva, Ana Carolina B. C. Rodrigues, Larissa M. Bomfim, Rosane B. Dias, Caroline B. S. Sales, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Alzir A. Batista, Daniel P. Bezerra
Published 2019-07-01

Biological and physical approaches on the role of piplartine (piperlongumine) in cancer

by Tiago Henrique, Caroline de F. Zanon, Ana P. Girol, Ana Carolina Buzzo Stefanini, Nayara S. de A. Contessoto, Nelson J. F. da Silveira, Daniel P. Bezerra, Edilberto R. Silveira, José M. Barbosa-Filho, Marinonio L. Cornélio, Sonia M. Oliani, Eloiza H. Tajara
Published 2020-12-01

Cytotoxic Alkaloids from the Stem of Xylopia laevigata

by Leociley R. A. Menezes, Cinara O. D´Sousa Costa, Ana Carolina B. da C. Rodrigues, Felipe R. do E. Santo, Angelita Nepel, Lívia M. Dutra, Felipe M. A. Silva, Milena B. P. Soares, Andersson Barison, Emmanoel V. Costa, Daniel P. Bezerra
Published 2016-07-01

Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues.

by Daniel Nascimento do Amaral, Bruno C Cavalcanti, Daniel P Bezerra, Paulo Michel P Ferreira, Rosane de Paula Castro, José Ricardo Sabino, Camila Maria Longo Machado, Roger Chammas, Claudia Pessoa, Carlos M R Sant'Anna, Eliezer J Barreiro, Lídia Moreira Lima
Published 2014-01-01

In vitro and in vivo growth inhibition of human acute promyelocytic leukemia HL-60 cells by Guatteria megalophylla Diels (Annonaceae) leaf essential oil

by Rafaela G.A. Costa, Talita A. da Anunciação, Morgana de S. Araujo, César A. Souza, Rosane B. Dias, Caroline B.S. Sales, Clarissa A.G. Rocha, Milena B.P. Soares, Felipe M.A. da Silva, Hector H.F. Koolen, Emmanoel V. Costa, Daniel P. Bezerra
Published 2020-02-01

Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid...

by Ana Carolina B. da C. Rodrigues, Larissa M. Bomfim, Sara P. Neves, Milena B.P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Emmanoel V. Costa, Felipe M.A. da Silva, Waldireny C. Rocha, Hector H.F. Koolen, Daniel P. Bezerra
Published 2021-10-01

Antitumor Effect of the Essential Oil from the Leaves of <i>Croton</i> <i>matourensis</i> Aubl. (Euphorbiaceae)

by Emilly J. S. P. de Lima, Rafaela G. Alves, Gigliola M. A. D´Elia, Talita A. da Anunciação, Valdenizia R. Silva, Luciano de S. Santos, Milena B. P. Soares, Nállarett M. D. Cardozo, Emmanoel V. Costa, Felipe M. A. da Silva, Hector H. F. Koolen, Daniel P. Bezerra
Published 2018-11-01

ALKALOIDS FROM LEAVES OF GUATTERIA POGONOPUS (ANNONACEAE) AND THEIR CYTOTOXICITIES

by Maria de Fátima C. Santos, José Eraldo N. Fontes, Lívia M. Dutra, Larissa M. Bomfim, Cinara O. D. Costa, Valéria R. S. Moraes, Andersson Barison, Milena B. P. Soares, Felipe Moura A. da Silva, Jackson R. G. da Silva Almeida, Héctor H. F. Koolen, Daniel P. Bezerra, Emmanoel Vilaça Costa

Essential oil from leaves of Conobea scoparioides (Cham. &amp; Schltdl.) Benth. (Plantaginaceae) causes cell death in HepG2 cells and inhibits tumor development in a xenograft mode...

by Emilly J.S.P. de Lima, Sheila S. Fontes, Mateus L. Nogueira, Valdenizia R. Silva, Luciano de S. Santos, Gigliola M.A. D’Elia, Rosane B. Dias, Caroline B.S. Sales, Clarissa A. Gurgel Rocha, Marcos A. Vannier-Santos, Milena B.P. Soares, Emmanoel V. Costa, Felipe M.A. da Silva, Hector H.F. Koolen, Daniel P. Bezerra
Published 2020-09-01

<i>Cyperus articulatus</i> L. (Cyperaceae) Rhizome Essential Oil Causes Cell Cycle Arrest in the G₂/M Phase and Cell Death in HepG2 Cells and Inhibits the Development of...

by Mateus L. Nogueira, Emilly J. S. P. de Lima, Asenate A. X. Adrião, Sheila S. Fontes, Valdenizia R. Silva, Luciano de S. Santos, Milena B. P. Soares, Rosane B. Dias, Clarissa A. Gurgel Rocha, Emmanoel V. Costa, Felipe M. A. da Silva, Marcos A. Vannier-Santos, Nállarett M. D. Cardozo, Hector H. F. Koolen, Daniel P. Bezerra
Published 2020-06-01