Immiscible inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and in...

by Mona Radwan, Jordan D Lilley, Ching-Seng Ang, Gavin E Reid, Danny M Hatters
Published 2020-01-01

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.

by Angelique R Ormsby, Dezerae Cox, James Daly, David Priest, Elizabeth Hinde, Danny M Hatters
Published 2020-01-01

Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src.

by Sevgi Irtegun, Rebecca J Wood, Angelique R Ormsby, Terrence D Mulhern, Danny M Hatters
Published 2013-01-01

Simultaneous binding of the anti-cancer IgM monoclonal antibody PAT-SM6 to low density lipoproteins and GRP78.

by Zachary Rosenes, Yee-Foong Mok, Shuo Yang, Michael D W Griffin, Terrence D Mulhern, Danny M Hatters, Frank Hensel, Geoffrey J Howlett
Published 2013-01-01

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

by Lorena Hidalgo San Jose, Mary Jean Sunshine, Christopher H. Dillingham, Bernadette A. Chua, Miriama Kruta, Yuning Hong, Danny M. Hatters, Robert A.J. Signer
Published 2020-01-01

The anti-cancer IgM monoclonal antibody PAT-SM6 binds with high avidity to the unfolded protein response regulator GRP78.

by Zachary Rosenes, Terrence D Mulhern, Danny M Hatters, Leodevico L Ilag, Barbara E Power, Chris Hosking, Frank Hensel, Geoffrey J Howlett, Yee-Foong Mok
Published 2012-01-01

A biosensor-based framework to measure latent proteostasis capacity

by Rebecca J. Wood, Angelique R. Ormsby, Mona Radwan, Dezerae Cox, Abhishek Sharma, Tobias Vöpel, Simon Ebbinghaus, Mikael Oliveberg, Gavin E. Reid, Alex Dickson, Danny M. Hatters
Published 2018-01-01

VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation

by Sarada D. Tetali, Madhu S. Budamagunta, Catalina Simion, Laura J. den Hartigh, Tamás Kálai, Kálmán Hideg, Danny M. Hatters, Karl H. Weisgraber, John C. Voss, John C. Rutledge
Published 2010-06-01

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.

by Jodi A Lee, Justin J Yerbury, Natalie Farrawell, Robert F Shearer, Patrick Constantinescu, Danny M Hatters, Wayne A Schroder, Andreas Suhrbier, Mark R Wilson, Darren N Saunders, Marie Ranson
Published 2015-01-01

A thiol probe for measuring unfolded protein load and proteostasis in cells

by Moore Z. Chen, Nagaraj S. Moily, Jessica L. Bridgford, Rebecca J. Wood, Mona Radwan, Trevor A. Smith, Zhegang Song, Ben Zhong Tang, Leann Tilley, Xiaohong Xu, Gavin E. Reid, Mahmoud A. Pouladi, Yuning Hong, Danny M. Hatters
Published 2017-09-01

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

by Yasmin M. Ramdzan, Mikhail M. Trubetskov, Angelique R. Ormsby, Estella A. Newcombe, Xiaojing Sui, Mark J. Tobin, Marie N. Bongiovanni, Sally L. Gras, Grant Dewson, Jason M.L. Miller, Steven Finkbeiner, Nagaraj S. Moily, Jonathan Niclis, Clare L. Parish, Anthony W. Purcell, Michael J. Baker, Jacqueline A. Wilce, Saboora Waris, Diana Stojanovski, Till Böcking, Ching-Seng Ang, David B. Ascher, Gavin E. Reid, Danny M. Hatters
Published 2017-05-01