Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity

by Yuan Zhang, Na Li, Heikyung Suh, Darrell J. Irvine
Published 2018-01-01

Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer

by Dobrin Draganov, Zhen Han, Aamir Rana, Nitasha Bennett, Darrell J. Irvine, Peter P. Lee
Published 2021-03-01

DNA-Loaded Cationic Liposomes Efficiently Function as a Vaccine against Malarial Proteins

by Wesley L. Fotoran, Rachele Santangelo, Beatriz N.M. de Miranda, Darrell J. Irvine, Gerhard Wunderlich
Published 2017-12-01

Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models

by Adrienne Rothschilds, Alice Tzeng, Naveen K. Mehta, Kelly D. Moynihan, Darrell J. Irvine, K. Dane Wittrup
Published 2019-05-01

Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine.

by James J Moon, Heikyung Suh, Mark E Polhemus, Christian F Ockenhouse, Anjali Yadava, Darrell J Irvine
Published 2012-01-01

High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function.

by Maria Hottelet Foley, Talitha Forcier, Elizabeth McAndrew, Michael Gonzalez, Huabiao Chen, Boris Juelg, Bruce D Walker, Darrell J Irvine
Published 2014-01-01

High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

by Yu-Sang Sabrina Yang, Prabhani U. Atukorale, Kelly D. Moynihan, Ahmet Bekdemir, Kavya Rakhra, Li Tang, Francesco Stellacci, Darrell J. Irvine
Published 2017-01-01

Erratum: High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry

by Yu-Sang Sabrina Yang, Prabhani U Atukorale, Kelly D. Moynihan, Ahmet Bekdemir, Kavya Rakhra, Li Tang, Francesco Stellacci, Darrell J Irvine
Published 2017-08-01

Temporal dynamics of intradermal cytokine response to tuberculin in Mycobacterium bovis BCG-vaccinated cattle using sampling microneedles

by Sabine Steinbach, Sasan Jalili-Firoozinezhad, Sreenidhi Srinivasan, Mariane B. Melo, Sonya Middleton, Timm Konold, Michael Coad, Paula T. Hammond, Darrell J. Irvine, Martin Vordermeier, Vivek Kapur
Published 2021-03-01

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

by Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin
Published 2015-03-01

Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.

by Richard Brad Jones, Rachel O'Connor, Stefanie Mueller, Maria Foley, Gregory L Szeto, Dan Karel, Mathias Lichterfeld, Colin Kovacs, Mario A Ostrowski, Alicja Trocha, Darrell J Irvine, Bruce D Walker
Published 2014-08-01

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

by Daniela Schmid, Chun Gwon Park, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Puerto, Yiran Zheng, James Maiarana, Gordon J. Freeman, Kai W. Wucherpfennig, Darrell J. Irvine, Michael S. Goldberg
Published 2017-11-01

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

by Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader
Published 2016-12-01

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages

by Robert J. Kimmerling, Gregory Lee Szeto, Jennifer W. Li, Alex S. Genshaft, Samuel W. Kazer, Kristofor R. Payer, Jacob de Riba Borrajo, Paul C. Blainey, Darrell J. Irvine, Alex K. Shalek, Scott R. Manalis
Published 2016-01-01

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization

by Colin Havenar-Daughton, Diane G. Carnathan, Archana V. Boopathy, Amit A. Upadhyay, Ben Murrell, Samantha M. Reiss, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Pallavi Dhadvai, Federico Viviano, Kirti Kaushik, Jinal N. Bhiman, Bryan Briney, Dennis R. Burton, Steven E. Bosinger, William R. Schief, Darrell J. Irvine, Guido Silvestri, Shane Crotty
Published 2019-11-01

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.

by R Brad Jones, Stefanie Mueller, Rachel O'Connor, Katherine Rimpel, Derek D Sloan, Dan Karel, Hing C Wong, Emily K Jeng, Allison S Thomas, James B Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A Ostrowski, Darrell J Irvine, Bruce D Walker
Published 2016-04-01

Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation

by Ke, Chyan Ying
Published 2015

Characterization of polystyrene-block-poly (acrylic acid) micelles

by Kohen, Naomi (Naomi T.)
Published 2006

An evaluation of cytokine-capture nanoparticle technology : stepping from bench-space into potential markets

by Hong, Julee Y. (Julee Yang-A.), 1980-
Published 2006

Immunization with synthetic nanoparticles to generate mucosal CD8 T Cell responses

by Li, Adrienne Victoria
Published 2013