Heterochromatin: an epigenetic point of view in aging

by Jong-Hyuk Lee, Edward W. Kim, Deborah L. Croteau, Vilhelm A. Bohr
Published 2020-09-01

Recent Advances in Understanding Werner Syndrome [version 1; referees: 3 approved]

by Raghavendra A. Shamanna, Deborah L. Croteau, Jong-Hyuk Lee, Vilhelm A. Bohr
Published 2017-09-01

WRN regulates pathway choice between classical and alternative non-homologous end joining

by Raghavendra A. Shamanna, Huiming Lu, Jessica K. de Freitas, Jane Tian, Deborah L. Croteau, Vilhelm A. Bohr
Published 2016-12-01

Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD.

by Stefanie C Wolski, Jochen Kuper, Petra Hänzelmann, James J Truglio, Deborah L Croteau, Bennett Van Houten, Caroline Kisker
Published 2008-06-01

RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

by Huiming Lu, Raghavendra A. Shamanna, Guido Keijzers, Roopesh Anand, Lene Juel Rasmussen, Petr Cejka, Deborah L. Croteau, Vilhelm A. Bohr
Published 2016-06-01

Age-related disease association of endogenous γ-H2AX foci in mononuclear cells derived from leukapheresis.

by Shepherd H Schurman, Christopher A Dunn, Rebecca Greaves, Binbing Yu, Luigi Ferrucci, Deborah L Croteau, Michael M Seidman, Vilhelm A Bohr
Published 2012-01-01

NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm −/− and old mice HSCs

by Le Zong, Mayuri Tanaka-Yano, Bongsoo Park, Hagai Yanai, Ferda T. Turhan, Deborah L. Croteau, Jane Tian, Evandro F. Fang, Vilhelm A. Bohr, Isabel Beerman
Published 2021-09-01

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

by Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L. Croteau, Marie-Christine Galas, Vilhelm A. Bohr
Published 2020-03-01

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).

by Joshua A Sommers, Tomasz Kulikowicz, Deborah L Croteau, Thomas Dexheimer, Dorjbal Dorjsuren, Ajit Jadhav, David J Maloney, Anton Simeonov, Vilhelm A Bohr, Robert M Brosh
Published 2019-01-01

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome

by Mustafa N. Okur, Beatrice Mao, Risako Kimura, Scott Haraczy, Tracy Fitzgerald, Kamren Edwards-Hollingsworth, Jane Tian, Wasif Osmani, Deborah L. Croteau, Matthew W. Kelley, Vilhelm A. Bohr
Published 2020-01-01

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

by Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr
Published 2017-12-01

Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease

by José Fernández Navarro, Deborah L. Croteau, Aleksandra Jurek, Zaneta Andrusivova, Beimeng Yang, Yue Wang, Benjamin Ogedegbe, Tahira Riaz, Mari Støen, Claus Desler, Lene Juel Rasmussen, Tone Tønjum, Marie-Christine Galas, Joakim Lundeberg, Vilhelm A. Bohr
Published 2020-10-01

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

by Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta, Domenica Caponio, Rojyar Khezri, Tyler G. Demarest, Yahyah Aman, David Figueroa, Marya Morevati, Ho-Joon Lee, Hisaya Kato, Henok Kassahun, Jong-Hyuk Lee, Deborah Filippelli, Mustafa Nazir Okur, Aswin Mangerich, Deborah L. Croteau, Yoshiro Maezawa, Costas A. Lyssiotis, Jun Tao, Koutaro Yokote, Tor Erik Rusten, Mark P. Mattson, Heinrich Jasper, Hilde Nilsen, Vilhelm A. Bohr
Published 2019-11-01