Therapy and long-term prophylaxis of vaccinia virus respiratory infections in mice with an adenovirus-vectored interferon alpha (mDEF201).

by Donald F Smee, Min-Hui Wong, Andrew Russell, Jane Ennis, Jeffrey D Turner
Published 2011-01-01

Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia vir...

by Donald F Smee, Min-Hui Wong, Brett L Hurst, Jane Ennis, Jeffrey D Turner
Published 2013-01-01

Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever.

by Michelle Mendenhall, Andrew Russell, Donald F Smee, Jeffery O Hall, Ramona Skirpstunas, Yousuke Furuta, Brian B Gowen
Published 2011-10-01

Biological Response Modifiers in Combination with Antivirals against Experimentally-Induced Virus Infections

by Robert W Sidwell, John H Huffman, Donald F Smee, John Gilbert, Roland K Robins, Meir Kende, John Huggins
Published 1992-01-01

Efficacy of combined therapy with amantadine, oseltamivir, and ribavirin in vivo against susceptible and amantadine-resistant influenza A viruses.

by Jack T Nguyen, Donald F Smee, Dale L Barnard, Justin G Julander, Matthew Gross, Menno D de Jong, Gregory T Went
Published 2012-01-01

The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice

by Kelly L. Warfield, Dale L. Barnard, Sven G. Enterlein, Donald F. Smee, Mansoora Khaliq, Aruna Sampath, Michael V. Callahan, Urban Ramstedt, Craig W. Day
Published 2016-03-01

Computationally engineered influenza antiviral affords broad prophylactic and therapeutic protection against influenza

by Deborah Heydenburg Fuller, Merika Treants Koday, Jorgen Nelson, Aaron Chevalier, Michael Koday, Donald F. Smee, Amy L. Hartman, Douglas S. Reed, Kelly Stefano Cole, David Baker
Published 2016-05-01

Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin.

by Brian B Gowen, Donald F Smee, Min-Hui Wong, Jeffery O Hall, Kie-Hoon Jung, Kevin W Bailey, John R Stevens, Yousuke Furuta, John D Morrey
Published 2008-01-01

Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog.

by Brian B Gowen, Min-Hui Wong, Deanna Larson, Wei Ye, Kie-Hoon Jung, Eric J Sefing, Ramona Skirpstunas, Donald F Smee, John D Morrey, Stewart W Schneller
Published 2010-09-01

Antiviral and Immunoenhancing Properties of 7-Thia-8-Oxoguanosine and Related Guanosine Analogues

by Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins
Published 1992-01-01

Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro.

by Jack T Nguyen, Justin D Hoopes, Minh H Le, Donald F Smee, Amy K Patick, Dennis J Faix, Patrick J Blair, Menno D de Jong, Mark N Prichard, Gregory T Went
Published 2010-01-01

Isolation and identification of compounds from Kalanchoe pinnata having human alphaherpesvirus and vaccinia virus antiviral activity

by Matthew Cryer, Kyle Lane, Mary Greer, Rex Cates, Scott Burt, Merritt Andrus, Jiping Zou, Paul Rogers, Marc D. H. Hansen, Jillybeth Burgado, Panayampalli Subbian Satheshkumar, Craig W. Day, Donald F. Smee, F. Brent Johnson
Published 2017-01-01

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response.

by Merika Treants Koday, Jorgen Nelson, Aaron Chevalier, Michael Koday, Hannah Kalinoski, Lance Stewart, Lauren Carter, Travis Nieusma, Peter S Lee, Andrew B Ward, Ian A Wilson, Ashley Dagley, Donald F Smee, David Baker, Deborah Heydenburg Fuller
Published 2016-02-01