Anti-tumour effects of a specific anti-ADAM17 antibody in an ovarian cancer model in vivo.

by Frances M Richards, Christopher J Tape, Duncan I Jodrell, Gillian Murphy
Published 2012-01-01

GEMMs as preclinical models for testing pancreatic cancer therapies

by Aarthi Gopinathan, Jennifer P. Morton, Duncan I. Jodrell, Owen J. Sansom
Published 2015-10-01

Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy.

by Robert C Jackson, Giovanni Y Di Veroli, Siang-Boon Koh, Ian Goldlust, Frances M Richards, Duncan I Jodrell
Published 2017-05-01

Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong...

by Claire M. Connell, Rebecca Brais, Hayley Whitaker, Sara Upponi, Ian Beh, Jane Risdall, Pippa Corrie, Tobias Janowitz, Duncan I. Jodrell
Published 2020-01-01

Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.

by Aurélie Courtin, Frances M Richards, Tashinga E Bapiro, Jo L Bramhall, Albrecht Neesse, Natalie Cook, Ben-Fillippo Krippendorff, David A Tuveson, Duncan I Jodrell
Published 2013-01-01

Quantifying Drug‐Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model

by Chiara Fornari, Lenka Oplustil O'Connor, Carmen Pin, Aaron Smith, James W.T. Yates, S.Y. Amy Cheung, Duncan I. Jodrell, Jerome T. Mettetal, Teresa A. Collins
Published 2019-11-01

Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer

by Soeren M. Buchholz, Robert G. Goetze, Shiv K. Singh, Christoph Ammer-Herrmenau, Frances M. Richards, Duncan I. Jodrell, Malte Buchholz, Patrick Michl, Volker Ellenrieder, Elisabeth Hessmann, Albrecht Neesse
Published 2020-07-01

Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach

by Timothy I. Johnson, Christopher J. Minteer, Daniel Kottmann, Charles R. Dunlop, Sandra Bernaldo de Quirós Fernández, Larissa S. Carnevalli, Yann Wallez, Alan Lau, Frances M. Richards, Duncan I. Jodrell
Published 2021-06-01

SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancerResearch in context

by Iswarya Ramu, Sören M. Buchholz, Melanie S. Patzak, Robert G. Goetze, Shiv K. Singh, Frances M. Richards, Duncan I. Jodrell, Bence Sipos, Philipp Ströbel, Volker Ellenrieder, Elisabeth Hessmann, Albrecht Neesse
Published 2019-10-01

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolitesResearch in context

by Melanie S. Patzak, Vijayalakshmi Kari, Shilpa Patil, Feda H. Hamdan, Robert G. Goetze, Marius Brunner, Jochen Gaedcke, Julia Kitz, Duncan I. Jodrell, Frances M. Richards, Christian Pilarsky, Robert Gruetzmann, Petra Rümmele, Thomas Knösel, Elisabeth Hessmann, Volker Ellenrieder, Steven A. Johnsen, Albrecht Neesse
Published 2019-02-01

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

by Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith, Simon J. Cook
Published 2019-11-01

CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

by Juliana B. Candido, Jennifer P. Morton, Peter Bailey, Andrew D. Campbell, Saadia A. Karim, Thomas Jamieson, Laura Lapienyte, Aarthi Gopinathan, William Clark, Ewan J. McGhee, Jun Wang, Monica Escorcio-Correia, Raphael Zollinger, Rozita Roshani, Lisa Drew, Loveena Rishi, Rebecca Arkell, T.R. Jeffry Evans, Colin Nixon, Duncan I. Jodrell, Robert W. Wilkinson, Andrew V. Biankin, Simon T. Barry, Frances R. Balkwill, Owen J. Sansom
Published 2018-05-01