Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection.

by Erika J Crosby, Michael H Goldschmidt, E John Wherry, Phillip Scott
Published 2014-02-01

A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection.

by Alison Crawford, Jill Marie Angelosanto, Kim Lynn Nadwodny, Shawn D Blackburn, E John Wherry
Published 2011-07-01

Correction: Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity.

by Timothy J Nice, Lisa C Osborne, Vesselin T Tomov, David Artis, E John Wherry, Herbert W Virgin
Published 2017-02-01

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity.

by Timothy J Nice, Lisa C Osborne, Vesselin T Tomov, David Artis, E John Wherry, Herbert W Virgin
Published 2016-06-01

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.

by Jang Eun Lee, Matthew C Walsh, Kyle L Hoehn, David E James, E John Wherry, Yongwon Choi
Published 2015-01-01

miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb

by Zeyu Chen, Erietta Stelekati, Makoto Kurachi, Sixiang Yu, Zhangying Cai, Sasikanth Manne, Omar Khan, Xiaolu Yang, E. John Wherry
Published 2017-09-01

The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii.

by Daniel P Beiting, Shinya Hidano, Julie E Baggs, Jeanne M Geskes, Qun Fang, E John Wherry, Christopher A Hunter, David S Roos, Sara Cherry
Published 2015-07-01

Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans.

by Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Senthil Kannan, Susan A Doyle, Hildegund C J Ertl, Kenneth E Schmader, E John Wherry
Published 2013-01-01

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species.

by Daniel P Beiting, Lucia Peixoto, Natalia S Akopyants, Stephen M Beverley, E John Wherry, David A Christian, Christopher A Hunter, Igor E Brodsky, David S Roos
Published 2014-01-01

Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells.

by George Makedonas, Natalie Hutnick, Danielle Haney, Alexandra C Amick, Jay Gardner, Gabriela Cosma, Adam R Hersperger, Douglas Dolfi, E John Wherry, Guido Ferrari, Michael R Betts
Published 2010-03-01

Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade.

by Nobuhiro Nakamoto, Hyosun Cho, Abraham Shaked, Kim Olthoff, Mary E Valiga, Mary Kaminski, Emma Gostick, David A Price, Gordon J Freeman, E John Wherry, Kyong-Mi Chang
Published 2009-02-01

Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity.

by Brian J Laidlaw, Vilma Decman, Mohammed-Alkhatim A Ali, Michael C Abt, Amaya I Wolf, Laurel A Monticelli, Krystyna Mozdzanowska, Jill M Angelosanto, David Artis, Jan Erikson, E John Wherry
Published 2013-03-01

Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection

by Sarah E. Henrickson, Sasikanth Manne, Douglas V. Dolfi, Kathleen D. Mansfield, Kaela Parkhouse, Rakesh D. Mistry, Elizabeth R. Alpern, Scott E. Hensley, Kathleen E. Sullivan, Susan E. Coffin, E. John Wherry
Published 2018-01-01

Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.

by Hyun Mu Shin, Varun N Kapoor, Gwanghun Kim, Peng Li, Hang-Rae Kim, M Suresh, Susan M Kaech, E John Wherry, Liisa K Selin, Warren J Leonard, Raymond M Welsh, Leslie J Berg
Published 2017-08-01

Norovirus-Specific CD8+ T Cell Responses in Human Blood and TissuesSummary

by Ajinkya Pattekar, Lena S. Mayer, Chi Wai Lau, Chengyang Liu, Olesya Palko, Meenakshi Bewtra, HPAP Consortium, Lisa C. Lindesmith, Paul D. Brewer-Jensen, Ralph S. Baric, Michael R. Betts, Ali Naji, E. John Wherry, Vesselin T. Tomov
Published 2021-01-01

Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways

by Ramin Sedaghat Herati, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cecile Alanio, Bertram Bengsch, Raj K. Kurupati, Senthil Kannan, Sasikanth Manne, Andrew V. Kossenkov, David H. Canaday, Susan A. Doyle, Hildegund C.J. Ertl, Kenneth E. Schmader, E. John Wherry
Published 2021-05-01

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

by Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe
Published 2020-06-01

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.

by Prakash K Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G Junger, Simon C Robson, E John Wherry, Galit Alter, Philip J R Goulder, Paul Klenerman, Arlene H Sharpe, Georg M Lauer, W Nicholas Haining
Published 2015-10-01

Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma

by David L. Bajor, Rosemarie Mick, Matthew J. Riese, Alex C. Huang, Brendan Sullivan, Lee P. Richman, Drew A. Torigian, Sangeeth M. George, Erietta Stelekati, Fang Chen, J. Joseph Melenhorst, Simon F. Lacey, Xiaowei Xu, E. John Wherry, Tara C. Gangadhar, Ravi K. Amaravadi, Lynn M. Schuchter, Robert H. Vonderheide
Published 2018-10-01

PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

by Gaurav Sharma, Rani Ojha, Estela Noguera-Ortega, Vito W. Rebecca, John Attanasio, Shujing Liu, Shengfu Piao, Jennifer J. Lee, Michael C. Nicastri, Sandra L. Harper, Amruta Ronghe, Vaibhav Jain, Jeffrey D. Winkler, David W. Speicher, Jerome Mastio, Phyllis A. Gimotty, Xiaowei Xu, E. John Wherry, Dmitry I. Gabrilovich, Ravi K. Amaravadi
Published 2020-09-01