No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice.

by Vivek Iyer, Katharina Boroviak, Mark Thomas, Brendan Doe, Laura Riva, Edward Ryder, David J Adams
Published 2018-07-01

The evolution of the DLK1-DIO3 imprinted domain in mammals.

by Carol A Edwards, Andrew J Mungall, Lucy Matthews, Edward Ryder, Dionne J Gray, Andrew J Pask, Geoffrey Shaw, Jennifer A M Graves, Jane Rogers, SAVOIR consortium, Ian Dunham, Marilyn B Renfree, Anne C Ferguson-Smith
Published 2008-06-01

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.

by J H Duncan Bassett, Apostolos Gogakos, Jacqueline K White, Holly Evans, Richard M Jacques, Anne H van der Spek, Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, Edward Ryder, David Sunter, Alan Boyde, Michael J Campbell, Peter I Croucher, Graham R Williams
Published 2012-01-01

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

by Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Published 2020-07-01

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.

by Amy E O'Connell, Maxim V Gerashchenko, Marie-Francoise O'Donohue, Samantha M Rosen, Eric Huntzinger, Diane Gleeson, Antonella Galli, Edward Ryder, Siqi Cao, Quinn Murphy, Shideh Kazerounian, Sarah U Morton, Klaus Schmitz-Abe, Vadim N Gladyshev, Pierre-Emmanuel Gleizes, Bertrand Séraphin, Pankaj B Agrawal
Published 2019-02-01

FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

by Carmen Ballesteros Reviriego, Simon Clare, Mark J Arends, Emma L Cambridge, Agnieszka Swiatkowska, Susana Caetano, Bushra Abu-Helil, Leanne Kane, Katherine Harcourt, David A Goulding, Diane Gleeson, Edward Ryder, Brendan Doe, Jacqueline K White, Louise van der Weyden, Gordon Dougan, David J Adams, Anneliese O Speak
Published 2019-01-01

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

by Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin
Published 2014-01-01

Common and distinct transcriptional signatures of mammalian embryonic lethality

by John E. Collins, Richard J. White, Nicole Staudt, Ian M. Sealy, Ian Packham, Neha Wali, Catherine Tudor, Cecilia Mazzeo, Angela Green, Emma Siragher, Edward Ryder, Jacqueline K. White, Irene Papatheodoru, Amy Tang, Anja Füllgrabe, Konstantinos Billis, Stefan H. Geyer, Wolfgang J. Weninger, Antonella Galli, Myriam Hemberger, Derek L. Stemple, Elizabeth Robertson, James C. Smith, Timothy Mohun, David J. Adams, Elisabeth M. Busch-Nentwich
Published 2019-06-01