Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocryst...

by Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter
Published 2019-01-01

A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds.

by Emanuela Screpanti, Stefano Santaguida, Tam Nguyen, Romano Silvestri, Rick Gussio, Andrea Musacchio, Ernest Hamel, Peter De Wulf
Published 2010-07-01

Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents

by Paola Oliva, Valentina Onnis, Elisa Balboni, Ernest Hamel, Francisco Estévez-Sarmiento, José Quintana, Francisco Estévez, Andrea Brancale, Salvatore Ferla, Stefano Manfredini, Romeo Romagnoli
Published 2020-05-01

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtai...

by Delia Preti, Romeo Romagnoli, Riccardo Rondanin, Barbara Cacciari, Ernest Hamel, Jan Balzarini, Sandra Liekens, Dominique Schols, Francisco Estévez-Sarmiento, José Quintana, Francisco Estévez
Published 2018-01-01

Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-<i>c</i>]pyridine Scaffold...

by Romeo Romagnoli, Filippo Prencipe, Paola Oliva, Barbara Cacciari, Jan Balzarini, Sandra Liekens, Ernest Hamel, Andrea Brancale, Salvatore Ferla, Stefano Manfredini, Matteo Zurlo, Alessia Finotti, Roberto Gambari
Published 2020-04-01

Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from <i>Bousigonia mekongensis</i> Inhibit Tubulin Polymerization

by Yu Zhang, Masuo Goto, Akifumi Oda, Pei-Ling Hsu, Ling-Li Guo, Yan-Hui Fu, Susan L. Morris-Natschke, Ernest Hamel, Kuo-Hsiung Lee, Xiao-Jiang Hao
Published 2019-03-01

Synthesis and biological evaluation of biaryl analogs of antitubulin compounds

by Camila Santos Suniga Tozatti, Rejane Gonçalves Diniz Khodyuk, Adriano Olimpio da Silva, Edson dos Anjos dos Santos, Marcos Serrou do Amaral, Dênis Pires de Lima, Ernest Hamel
Published 2012-01-01

Synthesis and biological activity of sulfur compounds showing structural analogy with combretastatin A-4

by Edson dos A. dos Santos, Paulo C. Prado, Wanderley R. de Carvalho, Ricardo V. de Lima, Adilson Beatriz, Dênis P. de Lima, Ernest Hamel, Marzena A. Dyba, Sergio Albuquerque
Published 2013-01-01

Synthesis and biological activity of sulfur compounds showing structural analogy with combretastatin A-4

by Edson dos A. dos Santos, Paulo C. Prado, Wanderley R. de Carvalho, Ricardo V. de Lima, Adilson Beatriz, Dênis P. de Lima, Ernest Hamel, Marzena A. Dyba, Sergio Albuquerque
Published 2013-01-01