Synthesis and Biological Evaluation of Analogs of Didehydroepiandrosterone as Potential New Anticancer Agents

by Eirik J. J. Solum, Sandra Liekens, Trond Vidar Hansen
Published 2020-07-01

Synthesis and antiproliferative activity of 2-(([1,2,4]triazolo[4,3-b]- pyridazin-6-yloxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine derivatives

by Miloš Ilić, Janez Ilaš, Sandra Liekens, Péter Mátyus, Danijel Kikelj
Published 2011-10-01

Sulfated Escherichia coli K5 polysaccharide derivatives inhibit dengue virus infection of human microvascular endothelial cells by interacting with the viral envelope protein E dom...

by Peter Vervaeke, Marijke Alen, Sam Noppen, Dominique Schols, Pasqua Oreste, Sandra Liekens
Published 2013-01-01

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

by Valentina Onnis, Monica Demurtas, Alessandro Deplano, Gianfranco Balboni, Anna Baldisserotto, Stefano Manfredini, Salvatore Pacifico, Sandra Liekens, Jan Balzarini
Published 2016-04-01

Skin Damages—Structure Activity Relationship of Benzimidazole Derivatives Bearing a 5-Membered Ring System

by Ernestine Nicaise Djuidje, Elisa Durini, Sabrina Sciabica, Elena Serra, Jan Balzarini, Sandra Liekens, Stefano Manfredini, Silvia Vertuani, Anna Baldisserotto
Published 2020-09-01

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition.

by Kathrin Reiser, Leen Mathys, Sophie Curbo, Christophe Pannecouque, Sam Noppen, Sandra Liekens, Lars Engman, Mathias Lundberg, Jan Balzarini, Anna Karlsson
Published 2016-01-01

Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation.

by Kurt Vermeire, Thomas W Bell, Victor Van Puyenbroeck, Anne Giraut, Sam Noppen, Sandra Liekens, Dominique Schols, Enno Hartmann, Kai-Uwe Kalies, Mark Marsh
Published 2014-12-01

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtai...

by Delia Preti, Romeo Romagnoli, Riccardo Rondanin, Barbara Cacciari, Ernest Hamel, Jan Balzarini, Sandra Liekens, Dominique Schols, Francisco Estévez-Sarmiento, José Quintana, Francisco Estévez
Published 2018-01-01

Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants.

by Alexander D Crawford, Sandra Liekens, Appolinary R Kamuhabwa, Jan Maes, Sebastian Munck, Roger Busson, Jef Rozenski, Camila V Esguerra, Peter A M de Witte
Published 2011-02-01

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models.

by Víctor M Castillo-Acosta, Luis M Ruiz-Pérez, Juan Etxebarria, Niels C Reichardt, Miguel Navarro, Yasuhiro Igarashi, Sandra Liekens, Jan Balzarini, Dolores González-Pacanowska
Published 2016-09-01

Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-<i>c</i>]pyridine Scaffold...

by Romeo Romagnoli, Filippo Prencipe, Paola Oliva, Barbara Cacciari, Jan Balzarini, Sandra Liekens, Ernest Hamel, Andrea Brancale, Salvatore Ferla, Stefano Manfredini, Matteo Zurlo, Alessia Finotti, Roberto Gambari
Published 2020-04-01

A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity.

by Jan Balzarini, Graciela Andrei, Emanuela Balestra, Dana Huskens, Christophe Vanpouille, Andrea Introini, Sonia Zicari, Sandra Liekens, Robert Snoeck, Antonín Holý, Carlo-Federico Perno, Leonid Margolis, Dominique Schols
Published 2013-01-01

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

by Rik Janssens, Rik Janssens, Daiane Boff, Daiane Boff, Pieter Ruytinx, Anneleen Mortier, Vincent Vanheule, Olav Larsen, Olav Larsen, Viktorija Daugvilaite, Mette M. Rosenkilde, Sam Noppen, Sandra Liekens, Dominique Schols, Ingrid De Meester, Ghislain Opdenakker, Sofie Struyf, Mauro M. Teixeira, Flávio A. Amaral, Paul Proost
Published 2018-08-01