Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism

by Fendt, Sarah-Maria, Stephanopoulos, Gregory, Keibler, Mark Andrew
Published 2014

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

by Fendt, Sarah-Maria, Bell, Eric L., Mayers, Jared R., Vokes, Natalie I., Stephanopoulos, Gregory, Keibler, Mark Andrew, Wasylenko, Thomas Michael, Guarente, Leonard Pershing, Vander Heiden, Matthew G., Olenchock, Benjamin
Published 2014

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

by Christen, Stefan, Lorendeau, Doriane, Schmieder, Roberta, Broekaert, Dorien, Metzger, Kristine, Veys, Koen, Elia, Ilaria, Buescher, Joerg Martin, Orth, Martin Franz, Grünewald, Thomas Georg Philipp, De Bock, Katrien, Fendt, Sarah-Maria, Davidson, Shawn Michael
Published 2017

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

by Csibi, Alfred, Fendt, Sarah-Maria, Li, Chenggang, Poulogiannis, George, Choo, Andrew Y, Chapski, Douglas J, Jeong, Seung Min, Dempsey, Jamie M., Parkhitko, Andrey, Morrison, Tasha, Henske, Elizabeth P., Haigis, Marcia C., Cantley, Lewis C., Stephanopoulos, Gregory, Yu, Jane, Blenis, John
Published 2014

Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH-Mutant Gliomas

by Wakimoto, H., Tanaka, S., Curry, W. T., Loebel, F., Zhao, D., Tateishi, K., Chen, J., Klofas, L. K., Lelic, N., Kim, J. C., Dias-Santagata, D., Ellisen, L. W., Borger, D. R., Fendt, Sarah-Maria, Batchelor, Tracy T., Iafrate, A. John, Cahill, D. P., Chi, A. S., Vander Heiden, Matthew G.
Published 2015

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

by Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark Andrew, Davidson, Shawn Michael, Wirth, Gregory J., Fiske, Brian Prescott, Mayers, Jared R., Schwab, Matthias, Bellinger, Gary, Csibi, Alfred, Patnaik, Akash, Blouin, Marie Jose, Cantley, Lewis C., Guarente, Leonard Pershing, Blenis, John, Pollak, Michael N., Olumi, Aria F., Vander Heiden, Matthew G., Stephanopoulos, Gregory
Published 2014

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

by Lunt, Sophia Y, Muralidhar, Vinayak, Israelsen, William J, Newhouse, Lauren, Ogrodzinski, Martin, Xu, Kali, Hollern, Daniel P, Bellinger, Gary, Christen, Stefan, Elia, Ilaria, Dinh, Anh T, Stephanopoulos, Gregory, Manalis, Scott R, Yaffe, Michael B, Andrechek, Eran R, Fendt, Sarah-Maria, Vander Heiden, Matthew G, Hosios, Aaron Marc, Gui, Dan Yi, Acevedo, Paula N. Marin, Dayton, Talya Lucia, Lunt, Sophia Y., Dinh, Anh T., Vander Heiden, Matthew G., Manalis, Scott R, Yaffe, Michael B, Hecht, Vivian Chaya
Published 2016