Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity

by Liu, Vivian M., Howell, Andrea J., Hosios, Aaron M., Li, Zhaoqi, Israelsen, William J., Vander Heiden, Matthew G.
Published 2022

Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity

by Liu, Vivian M., Howell, Andrea J., Hosios, Aaron M., Li, Zhaoqi, Israelsen, William J., Vander Heiden, Matthew G.
Published 2022

PKM2 is not required for colon cancer initiated by APC loss

by Sinnamon, Mark J, Georgeon, Larissa, Yilmaz, Omer H, Di Vizio, Dolores, Hung, Kenneth E, Vander Heiden, Matthew G, Lau, Allison N., Israelsen, William J., Sinnamon, Mark J., Dayton, Talya L., Hillis, Alissandra L., Hung, Kenneth E., Israelsen, William James, Roper, Jatin, Yilmaz, Omer, Vander Heiden, Matthew G., Dayton, Talya Lucia
Published 2018

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

by Qi, Weier, Keenan, Hillary A, Li, Qian, Ishikado, Atsushi, Kannt, Aimo, Sadowski, Thorsten, Yorek, Mark A, Wu, I-Hsien, Lockhart, Samuel, Coppey, Lawrence J, Pfenninger, Anja, Liew, Chong Wee, Qiang, Guifen, Burkart, Alison M, Hastings, Stephanie, Pober, David, Cahill, Christopher, Niewczas, Monika A, Israelsen, William J, Tinsley, Liane, Stillman, Isaac E, Amenta, Peter S, Feener, Edward P, Stanton, Robert C, King, George L, Vander Heiden, Matthew G.
Published 2018

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

by Lunt, Sophia Y, Muralidhar, Vinayak, Israelsen, William J, Newhouse, Lauren, Ogrodzinski, Martin, Xu, Kali, Hollern, Daniel P, Bellinger, Gary, Christen, Stefan, Elia, Ilaria, Dinh, Anh T, Stephanopoulos, Gregory, Manalis, Scott R, Yaffe, Michael B, Andrechek, Eran R, Fendt, Sarah-Maria, Vander Heiden, Matthew G, Hosios, Aaron Marc, Gui, Dan Yi, Acevedo, Paula N. Marin, Dayton, Talya Lucia, Lunt, Sophia Y., Dinh, Anh T., Vander Heiden, Matthew G., Manalis, Scott R, Yaffe, Michael B, Hecht, Vivian Chaya
Published 2016

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

by Walsh, Martin J., Brimacombe, Kyle R., Veith, Henrike, Bougie, James M., Daniel, Thomas, Leister, William, Cantley, Lewis C., Vander Heiden, Matthew G., Shen, Min, Auld, Douglas S., Thomas, Craig J., Boxer, Matthew B., Israelsen, William James
Published 2015