An adequate human T cell repertoire from a single T cell progenitor: Lessons from an experiment of nature

by Kirsten Canté-Barrett, Frank J.T. Staal
Published 2020-10-01

Cell Signaling Pathway Reporters in Adult Hematopoietic Stem Cells

by Jolanda. J.D. de Roo, Frank. J.T. Staal
Published 2020-10-01

The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors

by Veronica Della Chiara, Lucia Daxinger, Frank J. T. Staal
Published 2021-04-01

Autologous Stem-Cell-Based Gene Therapy for Inherited Disorders: State of the Art and Perspectives

by Frank J. T. Staal, Alessandro Aiuti, Alessandro Aiuti, Marina Cavazzana
Published 2019-10-01

Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?

by Imen Jridi, Kirsten Canté-Barrett, Karin Pike-Overzet, Frank J. T. Staal
Published 2021-02-01

Aberrant Wnt Signaling in Leukemia

by Frank J. T. Staal, Farbod Famili, Laura Garcia Perez, Karin Pike-Overzet
Published 2016-08-01

Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective

by Indu Khatri, Indu Khatri, Frank J. T. Staal, Jacques J. M. van Dongen
Published 2020-09-01

Ex Vivo Expansion of Hematopoietic Stem Cells for Therapeutic Purposes: Lessons from Development and the Niche

by Parisa Tajer, Karin Pike-Overzet, Sagrario Arias, Menzo Havenga, Frank J.T. Staal
Published 2019-02-01

Corrigendum: Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspec...

by Indu Khatri, Indu Khatri, Frank J. T. Staal, Jacques J. M. van Dongen
Published 2021-04-01

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells

by Farbod Famili, Martijn H. Brugman, Erdogan Taskesen, Brigitta E.A. Naber, Riccardo Fodde, Frank J.T. Staal
Published 2016-05-01

Preclinical Development of Autologous Hematopoietic Stem Cell-Based Gene Therapy for Immune Deficiencies: A Journey from Mouse Cage to Bed Side

by Laura Garcia-Perez, Anita Ordas, Kirsten Canté-Barrett, Pauline Meij, Karin Pike-Overzet, Arjan Lankester, Frank J. T. Staal
Published 2020-06-01

Combining Mobilizing Agents with Busulfan to Reduce Chemotherapy-Based Conditioning for Hematopoietic Stem Cell Transplantation

by Laura Garcia-Perez, Lieke van Roon, Marco W. Schilham, Arjan C. Lankester, Karin Pike-Overzet, Frank J.T. Staal
Published 2021-04-01

B-1 cells and B-1 cell precursors prompt different responses to Wnt signaling.

by Lika Osugui, Jolanda J de Roo, Vivian Cristina de Oliveira, Ana Clara Pires Sodré, Frank J T Staal, Ana Flavia Popi
Published 2018-01-01

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

by Peiman Shooshtarizadeh, Anne Helness, Charles Vadnais, Nelleke Brouwer, Hugues Beauchemin, Riyan Chen, Halil Bagci, Frank J. T. Staal, Jean-François Coté, Tarik Möröy
Published 2019-03-01

A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes

by Laura Garcia-Perez, Marja C.J.A. van Eggermond, Elisa Maietta, Marie-Louise P. van der Hoorn, Karin Pike-Overzet, Frank J. T. Staal
Published 2021-01-01

A Small Key for a Heavy Door: Genetic Therapies for the Treatment of Hemoglobinopathies

by Hidde A. Zittersteijn, Cornelis L. Harteveld, Stefanie Klaver-Flores, Arjan C. Lankester, Rob C. Hoeben, Frank J. T. Staal, Manuel A. F. V. Gonçalves
Published 2021-02-01

Genomic Engineering in Human Hematopoietic Stem Cells: Hype or Hope?

by Stefanie Klaver-Flores, Hidde A. Zittersteijn, Kirsten Canté-Barrett, Arjan Lankester, Rob C. Hoeben, Manuel A. F. V. Gonçalves, Karin Pike-Overzet, Frank J. T. Staal
Published 2021-01-01

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests

by Maria Themeli, Amiet Chhatta, Hester Boersma, Henk Jan Prins, Martijn Cordes, Edwin de Wilt, Aïda Shahrabi Farahani, Bart Vandekerckhove, Mirjam van der Burg, Rob C. Hoeben, Frank J.T. Staal, Harald M.M. Mikkers
Published 2020-02-01

The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

by Machteld M Tiemessen, Miranda R M Baert, Tom Schonewille, Martijn H Brugman, Farbod Famili, Daniela C F Salvatori, Jules P P Meijerink, Ugur Ozbek, Hans Clevers, Jacques J M van Dongen, Frank J T Staal
Published 2012-01-01

The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice

by Geerte Hoeke, P. Padmini S.J. Khedoe, Janna A. van Diepen, Karin Pike-Overzet, Britt van de Ven, Nadia Vazirpanah, Isabel Mol, Pieter S. Hiemstra, Frank J.T. Staal, Rinke Stienstra, Mihai G. Netea, Charles A. Dinarello, Patrick C.N. Rensen, Jimmy F.P. Berbée
Published 2017-08-01