Analgesic drug development: proof-of-mechanism and proof-of-concept in early phase clinical studies

by Hemme J. Hijma, MSc, Geert Jan Groeneveld, MD, PhD
Published 2021-06-01

Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders

by Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld
Published 2021-02-01

A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial partici...

by Samantha Prins, Ahnjili Zhuparris, Ellen P. Hart, Robert-Jan Doll, Geert Jan Groeneveld
Published 2021-07-01

Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Nav1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects

by Pieter Siebenga, Guido vanAmerongen, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman, Richard Butt, Geert Jan Groeneveld
Published 2020-03-01

False negatives in GBA1 sequencing due to polymerase dependent allelic imbalance

by Jonas M. den Heijer, Arnoud Schmitz, Peter Lansbury, Valerie C. Cullen, Dana C. Hilt, Vincenzo Bonifati, Geert Jan Groeneveld
Published 2021-01-01

EEG machine learning for accurate detection of cholinergic intervention and Alzheimer’s disease

by Sonja Simpraga, Ricardo Alvarez-Jimenez, Huibert D. Mansvelder, Joop M. A. van Gerven, Geert Jan Groeneveld, Simon-Shlomo Poil, Klaus Linkenkaer-Hansen
Published 2017-07-01

Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

by Tian Qin, Samantha Prins, Geert Jan Groeneveld, Gerard Van Westen, Helga E. de Vries, Yin Cheong Wong, Luc J.M. Bischoff, Elizabeth C.M. de Lange
Published 2020-04-01

Methylphenidate and galantamine in patients with vascular cognitive impairment–the proof-of-principle study STREAM-VCI

by Jolien F. Leijenaar, Geert Jan Groeneveld, Erica S. Klaassen, Anna E. Leeuwis, Philip Scheltens, Henry C. Weinstein, Joop M. A. van Gerven, Frederik Barkhof, Wiesje M. van der Flier, Niels D. Prins
Published 2020-01-01

Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending d...

by Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart, Erica S. Klaassen, Robert Jan Doll, Giles A. Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H. Marshall, David M. Cross, Geert Jan Groeneveld, Pradeep J. Nathan
Published 2021-04-01