A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer’s disease

by Niels D. Prins, John E. Harrison, Hui-May Chu, Kelly Blackburn, John J. Alam, Philip Scheltens, for the REVERSE-SD Study Investigators
Published 2021-05-01

Microbleeds are associated with depressive symptoms in Alzheimer's disease

by Anna E. Leeuwis, Niels D. Prins, Astrid M. Hooghiemstra, Marije R. Benedictus, Philip Scheltens, Frederik Barkhof, Wiesje M. van derFlier
Published 2018-01-01

Methylphenidate and galantamine in patients with vascular cognitive impairment–the proof-of-principle study STREAM-VCI

by Jolien F. Leijenaar, Geert Jan Groeneveld, Erica S. Klaassen, Anna E. Leeuwis, Philip Scheltens, Henry C. Weinstein, Joop M. A. van Gerven, Frederik Barkhof, Wiesje M. van der Flier, Niels D. Prins
Published 2020-01-01

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study

by Philip Scheltens, Merja Hallikainen, Timo Grimmer, Thomas Duning, Alida A Gouw, Charlotte E Teunissen, Alle Meije Wink, Paul Maruff, John Harrison, Caroline M van Baal, Suzanne Bruins, Inge Lues, Niels D Prins
Published 2018-10-01

Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid

by Rutger Heinen, Onno N. Groeneveld, Frederik Barkhof, Jeroen deBresser, Lieza G. Exalto, Hugo J. Kuijf, Niels D. Prins, Philip Scheltens, Wiesje M. vander Flier, Geert Jan Biessels, the TRACE‐VCI study group
Published 2020-01-01

Sex differences in memory clinic patients with possible vascular cognitive impairment

by Lieza G. Exalto, Jooske M. F. Boomsma, Rosha Babapour Mofrad, Frederik Barkhof, Onno N. Groeneveld, Rutger Heinen, Hugo J. Kuijf, Anna E. Leeuwis, Niels D. Prins, Geert Jan Biessels, Wiesje M. vd Flier, TRACE‐VCI study group
Published 2020-01-01

Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort stud...

by Inge M W Verberk, MSc, Malika B Laarhuis, MSc, Karlijn A van den Bosch, MSc, Jarith L Ebenau, MD, Mardou van Leeuwenstijn, Niels D Prins, MD, Philip Scheltens, ProfMD, Charlotte E Teunissen, ProfPhD, Wiesje M van der Flier, ProfPhD
Published 2021-02-01

Cerebral Blood Flow and Cognitive Functioning in a Community-Based, Multi-Ethnic Cohort: The SABRE Study

by Anna E. Leeuwis, Lorna A. Smith, Andrew Melbourne, Alun D. Hughes, Alun D. Hughes, Marcus Richards, Niels D. Prins, Magdalena Sokolska, David Atkinson, Therese Tillin, Hans R. Jäger, Nish Chaturvedi, Nish Chaturvedi, Wiesje M. van der Flier, Wiesje M. van der Flier, Frederik Barkhof, Frederik Barkhof
Published 2018-09-01

Prediction of poor clinical outcome in vascular cognitive impairment: TRACE‐VCI study

by Jooske M.F. Boomsma, Lieza G. Exalto, Frederik Barkhof, Christopher L.H. Chen, Saima Hilal, Anna E. Leeuwis, Niels D. Prins, Francis N. Saridin, Philip Scheltens, Charlotte E. Teunissen, Jurre H. Verwer, Henry C. Weinstein, Wiesje M. vander Flier, Geert Jan Biessels, the TRACE‐VCI study group
Published 2020-01-01

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results

by Rosalinde E. R. Slot, Sander C. J. Verfaillie, Jozefien M. Overbeek, Tessa Timmers, Linda M. P. Wesselman, Charlotte E. Teunissen, Annemiek Dols, Femke H. Bouwman, Niels D. Prins, Frederik Barkhof, Adriaan A. Lammertsma, Bart N. M. Van Berckel, Philip Scheltens, Sietske A. M. Sikkes, Wiesje M. Van der Flier
Published 2018-08-01

Dietary Patterns Are Related to Clinical Characteristics in Memory Clinic Patients with Subjective Cognitive Decline: The SCIENCe Project

by Linda M. P. Wesselman, Astrid S. Doorduijn, Francisca A. de Leeuw, Sander C. J. Verfaillie, Mardou van Leeuwenstijn-Koopman, Rosalinde E. R. Slot, Maartje I. Kester, Niels D. Prins, Ondine van de Rest, Marian A. E. de van der Schueren, Philip Scheltens, Sietske A. M. Sikkes, Wiesje M. van der Flier
Published 2019-05-01

Personalized risk for clinical progression in cognitively normal subjects—the ABIDE project

by Ingrid S. van Maurik, Rosalinde E. R. Slot, Sander C. J. Verfaillie, Marissa D. Zwan, Femke H. Bouwman, Niels D. Prins, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Mike P. Wattjes, Jose Luis Molinuevo, Lorena Rami, Steffen Wolfsgruber, Oliver Peters, Frank Jessen, Johannes Berkhof, Wiesje M. van der Flier, for the Alzheimer’s Disease Neuroimaging Initiative
Published 2019-04-01

Amyloid-β Load Is Related to Worries, but Not to Severity of Cognitive Complaints in Individuals With Subjective Cognitive Decline: The SCIENCe Project

by Sander C. J. Verfaillie, Sander C. J. Verfaillie, Sander C. J. Verfaillie, Tessa Timmers, Tessa Timmers, Tessa Timmers, Rosalinde E. R. Slot, Rosalinde E. R. Slot, Chris W. J. van der Weijden, Chris W. J. van der Weijden, Linda M. P. Wesselman, Linda M. P. Wesselman, Niels D. Prins, Niels D. Prins, Sietske A. M. Sikkes, Sietske A. M. Sikkes, Sietske A. M. Sikkes, Maqsood Yaqub, Maqsood Yaqub, Annemiek Dols, Annemiek Dols, Annemiek Dols, Adriaan A. Lammertsma, Adriaan A. Lammertsma, Philip Scheltens, Philip Scheltens, Rik Ossenkoppele, Rik Ossenkoppele, Rik Ossenkoppele, Bart N. M. van Berckel, Bart N. M. van Berckel, Wiesje M. van der Flier, Wiesje M. van der Flier, Wiesje M. van der Flier
Published 2019-01-01

Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings

by Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D. Prins, Alina Solomon, Brian D. Tom, Henrik Zetterberg, Marissa Zwan, Craig W. Ritchie, Philip Scheltens, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser, for the IMI-EPAD collaborators
Published 2020-01-01