Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues.

by Geoffrey D Coxon, Derek Craig, Rosa Milagros Corrales, Emilie Vialla, Laila Gannoun-Zaki, Laurent Kremer
Published 2013-01-01

Synthesis and crystal structures of 3-hydroxy-2,4-dimethyl-2H-thiophen-5-one and 3-hydroxy-4-methyl-2H-thiophen-5-one

by Asma Nashawi, Christopher P. Lawson, M. Omar Abdel-Sattar, Joop H. ter Horst, Geoffrey D. Coxon, Alan R. Kennedy
Published 2020-07-01

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.

by Anuradha Alahari, Xavier Trivelli, Yann Guérardel, Lynn G Dover, Gurdyal S Besra, James C Sacchettini, Robert C Reynolds, Geoffrey D Coxon, Laurent Kremer
Published 2007-12-01

Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH.

by Qosay Al-Balas, Nahoum G Anthony, Bilal Al-Jaidi, Amani Alnimr, Grainne Abbott, Alistair K Brown, Rebecca C Taylor, Gurdyal S Besra, Timothy D McHugh, Stephen H Gillespie, Blair F Johnston, Simon P Mackay, Geoffrey D Coxon
Published 2009-01-01