Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription.

by Michelle Zanoni, David Palesch, Claudia Pinacchio, Maura Statzu, Gregory K Tharp, Mirko Paiardini, Ann Chahroudi, Steven E Bosinger, Jack Yoon, Bryan Cox, Guido Silvestri, Deanna A Kulpa
Published 2020-09-01

Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion

by Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Anke Heigele, Gregory K. Tharp, Prachi Mehrotra Gupta, Sydney Nelson, Steven Bosinger, Laura Parodi, Luis Giavedoni, Guido Silvestri, Daniel Sauter, Christiane Stahl-Hennig, Frank Kirchhoff
Published 2020-02-01

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

by Amit A. Upadhyay, Robert C. Kauffman, Amber N. Wolabaugh, Alice Cho, Nirav B. Patel, Samantha M. Reiss, Colin Havenar-Daughton, Reem A. Dawoud, Gregory K. Tharp, Iñaki Sanz, Bali Pulendran, Shane Crotty, F. Eun-Hyung Lee, Jens Wrammert, Steven E. Bosinger
Published 2018-03-01

Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replica...

by Krystelle Nganou-Makamdop, James M Billingsley, Zachary Yaffe, Gregory O'Connor, Gregory K Tharp, Amy Ransier, Farida Laboune, Rodrigo Matus-Nicodemos, Andrea Lerner, Lavina Gharu, Jennifer M Robertson, Mandy L Ford, Martin Schlapschy, Nadine Kuhn, Alexandra Lensch, Jeffrey Lifson, Martha Nason, Arne Skerra, Gideon Schreiber, Steven E Bosinger, Daniel C Douek
Published 2018-08-01

Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.

by Michelle Y-H Lee, Amit A Upadhyay, Hasse Walum, Chi N Chan, Reem A Dawoud, Christine Grech, Justin L Harper, Kirti A Karunakaran, Sydney A Nelson, Ernestine A Mahar, Kyndal L Goss, Diane G Carnathan, Barbara Cervasi, Kiran Gill, Gregory K Tharp, Elizabeth R Wonderlich, Vijayakumar Velu, Simon M Barratt-Boyes, Mirko Paiardini, Guido Silvestri, Jacob D Estes, Steven E Bosinger
Published 2021-06-01