The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.

by Marc Daigneault, Julie A Preston, Helen M Marriott, Moira K B Whyte, David H Dockrell
Published 2010-01-01

Developing Novel Host-Based Therapies Targeting Microbicidal Responses in Macrophages and Neutrophils to Combat Bacterial Antimicrobial Resistance

by Katie Watson, Katie Watson, Clark D. Russell, Clark D. Russell, Clark D. Russell, J. Kenneth Baillie, Kev Dhaliwal, J. Ross Fitzgerald, Timothy J. Mitchell, A. John Simpson, Stephen A. Renshaw, David H. Dockrell, David H. Dockrell
Published 2020-06-01

Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease

by Bethany M. Hughes, Charlotte S. Burton, Abigail Reese, Maisha F. Jabeen, Carl Wright, Jessica Willis, Nika Khoshaein, Elizabeth K. Marsh, Peter Peachell, Shao C. Sun, David H. Dockrell, David H. Dockrell, Helen M. Marriott, Ian Sabroe, Alison M. Condliffe, Lynne R. Prince
Published 2019-07-01

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

by Lynne R Prince, Nicola C Maxwell, Sharonjit K Gill, David H Dockrell, Ian Sabroe, Eamon P McGreal, Sailesh Kotecha, Moira K Whyte
Published 2014-01-01

Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages

by Joby Cole, Joby Cole, Joby Cole, Joby Cole, Adrienn Angyal, Richard D. Emes, Richard D. Emes, Tim John Mitchell, Mark J. Dickman, David H. Dockrell
Published 2021-05-01

Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.

by Nazia Chaudhuri, Hannah Jary, Simon Lea, Naimat Khan, Katie C Piddock, David H Dockrell, Ken Donaldson, Rodger Duffin, Dave Singh, Lisa C Parker, Ian Sabroe
Published 2012-01-01

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

by Martin A Bewley, Helen M Marriott, Calogero Tulone, Sheila E Francis, Timothy J Mitchell, Robert C Read, Benny Chain, Guido Kroemer, Moira K B Whyte, David H Dockrell
Published 2011-01-01

Pellino-1 Regulates the Responses of the Airway to Viral Infection

by Elizabeth K. Marsh, Elizabeth K. Marsh, Elizabeth C. Prestwich, Lynne Williams, Amber R. Hart, Clare F. Muir, Lisa C. Parker, Marnix R. Jonker, Irene H. Heijink, Wim Timens, Mark Fife, Tracy Hussell, Marc B. Hershenson, J. Kelley Bentley, Shao-Cong Sun, Ben S. Barksby, Lee A. Borthwick, James P. Stewart, Ian Sabroe, David H. Dockrell, David H. Dockrell, Helen M. Marriott
Published 2020-08-01

Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis...

by Bartłomiej Salamaga, Tomasz K Prajsnar, Ana Jareño-Martinez, Joost Willemse, Martin A Bewley, Françoise Chau, Tassadit Ben Belkacem, Annemarie H Meijer, David H Dockrell, Stephen A Renshaw, Stéphane Mesnage
Published 2017-07-01

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

by Marc Daigneault, Thushan I De Silva, Martin A Bewley, Julie A Preston, Helen M Marriott, Andrea M Mitchell, Timothy J Mitchell, Robert C Read, Moira K B Whyte, David H Dockrell
Published 2012-01-01

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

by Martin A Bewley, Kylie B R Belchamber, Kirandeep K Chana, Richard C Budd, Gavin Donaldson, Jadwiga A Wedzicha, Christopher E Brightling, Iain Kilty, Louise E Donnelly, Peter J Barnes, Dave Singh, Moira K B Whyte, David H Dockrell, COPDMAP
Published 2016-01-01

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

by Atiqur Rahman, Katherine M Henry, Kimberly D Herman, Alfred AR Thompson, Hannah M Isles, Claudia Tulotta, David Sammut, Julien JY Rougeot, Nika Khoshaein, Abigail E Reese, Kathryn Higgins, Caroline Tabor, Ian Sabroe, William J Zuercher, Caroline O Savage, Annemarie H Meijer, Moira KB Whyte, David H Dockrell, Stephen A Renshaw, Lynne R Prince
Published 2019-10-01

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

by Bo Li, Sara M. Clohisey, Bing Shao Chia, Bo Wang, Ang Cui, Thomas Eisenhaure, Lawrence D. Schweitzer, Paul Hoover, Nicholas J. Parkinson, Aharon Nachshon, Nikki Smith, Tim Regan, David Farr, Michael U. Gutmann, Syed Irfan Bukhari, Andrew Law, Maya Sangesland, Irit Gat-Viks, Paul Digard, Shobha Vasudevan, Daniel Lingwood, David H. Dockrell, John G. Doench, J. Kenneth Baillie, Nir Hacohen
Published 2020-01-01

­­­­­­­A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS­­­ [version 1; peer review: 1 approved, 3 approved with reservations]...

by Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Published 2021-02-01

­­­­­­­A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS­­­ [version 2; peer review: 1 approved, 3 approved with reservations]...

by Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Published 2021-05-01

A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts

by Fergal J. Duffy, Ethan Thompson, Katrina Downing, Sara Suliman, Harriet Mayanja-Kizza, Harriet Mayanja-Kizza, W. Henry Boom, Bonnie Thiel, January Weiner III, Stefan H. E. Kaufmann, Drew Dover, David L. Tabb, Hazel M. Dockrell, Tom H. M. Ottenhoff, Gerard Tromp, Thomas J. Scriba, Daniel E. Zak, Gerhard Walzl, the GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. Loxton, N. N. Chegou, S. Suliman, T. Scriba, H. Mahomed, M. Erasmus, O. Xasa, A. Veldsman, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong C, W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Published 2018-04-01