Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity

by Haggarty, Stephen J., Tsai, Li-Huei
Published 2016

Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration

by Gilleland, Cody Lee, Rohde, Christopher Benjamin, Samara, Chrysanthi, Yanik, Mehmet Fatih, Haggarty, Stephen J.
Published 2012

Microfluidic in vivo screen identifies compounds enhancing neuronal

by Haggarty, Stephen J., Norton, Stephanie, Samara, Chrysanthi, Gilleland, Cody Lee, Rohde, Christopher Benjamin, Yanik, Mehmet Fatih
Published 2010

 β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome

by Mellios, Nikolaos, Woodson, Jonathan, Garcia, Rodrigo, Crawford, Benjamin, Sharma, Jitendra, Sheridan, Steven, Sur, Mriganka, Haggarty, Stephen J.
Published 2015

A High-Throughput Screen for Wnt/β-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors

by Zhao, Wen-Ning, Cheng, Chialin, Theriault, Kraig M., Sheridan, Steven D., Tsai, Li-Huei, Haggarty, Stephen J.
Published 2015

Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation

by Ghosh, Balaram, Zhao, Wen-Ning, Reis, Surya A., Patnaik, Debasis, Fass, Daniel M., Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J.
Published 2018

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

by Theriault, Kraig M., Daheron, Laurence, Loring, Jeanne F., Sheridan, Steven, Reis, Surya A., Zhou, Fen, Madison, Jon M., Haggarty, Stephen J.
Published 2012

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

by Zhao, Wen-Ning, Ghosh, Balaram, Tyler, Marshall, Lalonde, Jasmin, Joseph, Nadine F., Kosaric, Nina, Fass, Daniel M., Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J.
Published 2020

Molecular Signatures of Human Induced Pluripotent Stem Cells Highlight Sex Differences and Cancer Genes

by Anguera, Montserrat C, Sadreyev, Ruslan, Zhang, Zhaoqing, Szanto, Attila, Payer, Bernhard, Sheridan, Steven D, Kwok, Showming, Haggarty, Stephen J., Sur, Mriganka, Alvarez, Jason, Gimelbrant, Alexander A., Mitalipova, Maisam, Kirby, James E, Lee, Jeannie T.
Published 2014

CHD8 Regulates Neurodevelopmental Pathways Associated with Autism Spectrum Disorder in Neural Progenitors

by Sugathan, Aarathi, Biagioli, Marta, Golzio, Christelle, Erdin, Serkan, Blumenthal, Ian, Manavalan, Poornima, Ragavendran, Ashok, Brand, Harrison, Lucente, Diane, Miles, Judith, Sheridan, Steven D., Stortchevoi, Alexei, Kellis, Manolis, Haggarty, Stephen J., Katsanis, Nicholas, Gusella, James F., Talkowski, Michael E.
Published 2015

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

by Mao, Yingwei, Ge, Xuecai, Frank, Christopher Lee, Madison, Jon M., Koehler, Angela Nicole, Doud, Mary Kathryn, Tassa, Carlos, Berry, Erin M., Soda, Takahiro, Singh, Karun K., Biechele, Travis, Petryshen, Tracey L., Moon, Randall T., Haggarty, Stephen J., Tsai, Li-Huei
Published 2015

An epigenetic blockade of cognitive functions in the neurodegenerating brain

by Rei, Damien, Guan, Ji-Song, Wang, Wen-Yuan, Seo, Jinsoo, Hennig, Krista M., Nieland, Thomas J., Fass, Daniel M., Kao, Patricia F., Kahn, Martin, Su, Susan C., Samiei, Alireza, Joseph, Nadine, Haggarty, Stephen J., Delalle, Ivana, Tsai, Li-Huei, Graff, Johannes
Published 2015

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

by Silva, M. Catarina, Sheridan, Steven D., Lucente, Diane, Gusella, James F., Dickerson, Bradford C., Haggarty, Stephen J., Tsai, Li-Huei, Seo, Jinsoo, Kritskiy, Oleg, Watson, Lauren Ashley, Barker, Scarlett Jazmine, Dey, Dilip Chandra, Raja, Waseem K, Lin, Yuan-Ta, Ko, Tak, Cho, Sukhee, Penney, Jay
Published 2018

Antidepressant Actions of Histone Deacetylase Inhibitors

by Haggarty, Stephen J., Covington III, Herbert E., Maze, Ian, LaPlant, Quincey C., Vialou, Vincent F., Ohnishi, Yoshinori N., Berton, Olivier, Fass, Daniel M., Renthal, William, Rush III, Augustus J., Wu, Emma Y., Ghose, Subroto, Krishnan, Vaishnav, Russo, Scott J., Tamminga, Carol, Nestler, Eric J.
Published 2010

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

by Fass, Daniel M., Reis, Surya A., Ghosh, Balaram, Hennig, Krista M., Joseph, Nadine F., Zhao, Wen-Ning, Nieland, Thomas J.F, Guan, Ji-Song, Groves Kuhnle, Chelsea E., Tang, Weiping, Barker, Douglas D., Mazitschek, Ralph, Schreiber, Stuart L., Tsai, Li-Huei, Haggarty, Stephen J.
Published 2016

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

by Nehme, Ralda, Zuccaro, Emanuela, Ghosh, Sulagna Dia, Li, Chenchen, Sherwood, John L., Pietilainen, Olli, Barrett, Lindy E., Limone, Francesco, Worringer, Kathleen A., Kommineni, Sravya, Zang, Ying, Cacchiarelli, Davide, Meissner, Alex, Adolfsson, Rolf, Haggarty, Stephen, Madison, Jon, Muller, Matthias, Arlotta, Paola, Fu, Zhanyan, Feng, Guoping, Eggan, Kevin
Published 2018

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

by Schroeder, Frederick A., Lewis, Michael C., Fass, Daniel M., Wagner, Florence F., Zhang, Yan-Ling, Hennig, Krista M., Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D., Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L., Hooker, Jacob M., Holson, Edward B., Haggarty, Stephen J., Petryshen, Tracey
Published 2013

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

by Cheng, Chialin, Reis, Surya A, Adams, Emily T, Fass, Daniel M, Angus, Steven P, Stuhlmiller, Timothy J, Richardson, Jared, Olafson, Hailey, Wang, Eric T, Patnaik, Debasis, Beauchamp, Roberta L, Feldman, Danielle A, Silva, M Catarina, Sur, Mriganka, Johnson, Gary L, Ramesh, Vijaya, Miller, Bruce L, Temple, Sally, Kosik, Kenneth S, Dickerson, Bradford C, Haggarty, Stephen J
Published 2021

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

by Joseph, Nadine F, Horn, Meryl E, Samiei, Alireza, Meng, Jia, Seo, Jinsoo, Rei, Damien, Bero, Adam W, Phan, Trongha X, Wagner, Florence, Holson, Edward, Xu, Jinbin, Sun, Jianjun, Neve, Rachael L, Mach, Robert H, Haggarty, Stephen J, Tsai, Li-Huei, Graff, Johannes, Joseph, Nadine F., Horn, Meryl E., Bero, Adam W., Phan, Trongha X., Neve, Rachael L.
Published 2016