Binding Sites Models, Molecular article priority journal protein domain Charged amino acids Computer Simulation Hepatitis C virus Humans Molecular Sequence Data Molecular dynamics simulation Mutation Protein Structure, Secondary Viral Envelope Proteins controlled study dimerization glycoprotein E1 glycoprotein E2 human hydrophobicity membrane permeability molecular dynamics nonhuman protein protein interaction 1,2-Dipalmitoylphosphatidylcholine ABC database Activation analysis Amino Acid Sequence Amino Acid Substitution Amino Acids