Exploring molecular genetics of bladder cancer: lessons learned from mouse models

by Imran Ahmad, Owen J. Sansom, Hing Y. Leung
Published 2012-05-01

Prostate gland lengths and iceball dimensions predict micturition functional outcome following salvage prostate cryotherapy in men with radiation recurrent prostate cancer.

by Imran Ahmad, Gabriela Kalna, Mohamed Ismail, Fiona Birrell, Sue Asterling, Elaine McCartney, Damien Greene, John Davies, Hing Y Leung
Published 2013-01-01

Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL, and interleukin-12

by Najla Altwaijry, Sukrut Somani, John A. Parkinson, Rothwelle J. Tate, Patricia Keating, Monika Warzecha, Graeme R. Mackenzie, Hing Y. Leung, Christine Dufès
Published 2018-01-01

Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis

by Keiran D Clement, Lizzy Day, Helen Rooney, Matt Neilson, Fiona Birrell, Mark Salji, Elizabeth Norman, Ross Clark, Amit Patel, John Morrison, Hing Y Leung
Published 2021-01-01

Human α(2)β(1)(HI) CD133(+VE) epithelial prostate stem cells express low levels of active androgen receptor.

by Stuart C Williamson, Anastasia C Hepburn, Laura Wilson, Kelly Coffey, Claudia A Ryan-Munden, Deepali Pal, Hing Y Leung, Craig N Robson, Rakesh Heer
Published 2012-01-01

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder

by Imran Ahmad, Lukram Babloo Singh, Mona Foth, Carol-Ann Morris, Makoto Mark Taketo, Xue-Ru Wu, Hing Y. Leung, Owen J. Sansom, Tomoko Iwata
Published 2011-07-01

Targeting the DNA double strand break repair machinery in prostate cancer.

by Fadhel S Shaheen, Pawel Znojek, Ann Fisher, Martin Webster, Ruth Plummer, Luke Gaughan, Graeme C M Smith, Hing Y Leung, Nicola J Curtin, Craig N Robson
Published 2011-01-01

Application of Holistic Liquid Chromatography-High Resolution Mass Spectrometry Based Urinary Metabolomics for Prostate Cancer Detection and Biomarker Discovery.

by Tong Zhang, David G Watson, Lijie Wang, Muhammad Abbas, Laura Murdoch, Lisa Bashford, Imran Ahmad, Nga-Yee Lam, Anthony C F Ng, Hing Y Leung
Published 2013-01-01

Gene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the <i>JMJD6</i> Regulon in Clinical Prostate Cancer

by Mario Cangiano, Magda Grudniewska, Mark J. Salji, Matti Nykter, Guido Jenster, Alfonso Urbanucci, Zoraide Granchi, Bart Janssen, Graham Hamilton, Hing Y. Leung, Inès J. Beumer
Published 2021-04-01

RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development

by Renaud Mevel, Ivana Steiner, Susan Mason, Laura CA Galbraith, Rahima Patel, Muhammad ZH Fadlullah, Imran Ahmad, Hing Y Leung, Pedro Oliveira, Karen Blyth, Esther Baena, Georges Lacaud
Published 2020-10-01

The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration

by Jennifer Munkley, Urszula L. McClurg, Karen E. Livermore, Ingrid Ehrmann, Bridget Knight, Paul Mccullagh, John Mcgrath, Malcolm Crundwell, Lorna W. Harries, Hing Y. Leung, Ian G. Mills, Craig N. Robson, Prabhakar Rajan, David J. Elliott
Published 2017-07-01

Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability

by Jennifer Munkley, Daniel Vodak, Karen E. Livermore, Katherine James, Brian T. Wilson, Bridget Knight, Paul Mccullagh, John Mcgrath, Malcolm Crundwell, Lorna W. Harries, Hing Y. Leung, Craig N. Robson, Ian G. Mills, Prabhakar Rajan, David J. Elliott
Published 2016-06-01

Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.

by Prabhakar Rajan, Caroline Dalgliesh, Phillippa J Carling, Thomas Buist, Chaolin Zhang, Sushma N Grellscheid, Kelly Armstrong, Jacqueline Stockley, Cedric Simillion, Luke Gaughan, Gabriela Kalna, Michael Q Zhang, Craig N Robson, Hing Y Leung, David J Elliott
Published 2011-01-01

Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of Mcm5 and nuclear matrix protein 22.

by John D Kelly, Tim J Dudderidge, Alex Wollenschlaeger, Odu Okoturo, Keith Burling, Fiona Tulloch, Ian Halsall, Teresa Prevost, Andrew Toby Prevost, Joana C Vasconcelos, Wendy Robson, Hing Y Leung, Nikhil Vasdev, Robert S Pickard, Gareth H Williams, Kai Stoeber
Published 2012-01-01

Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1

by Rachana Patel, Janis Fleming, Ernest Mui, Carolyn Loveridge, Peter Repiscak, Arnaud Blomme, Victoria Harle, Mark Salji, Imran Ahmad, Katy Teo, Freddie C Hamdy, Ann Hedley, Niels van den Broek, Gillian Mackay, Joanne Edwards, Owen J Sansom, Hing Y Leung
Published 2018-04-01

Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis

by Chara Ntala, Mark Salji, Jonathan Salmond, Leah Officer, Ana Vieira Teodosio, Arnaud Blomme, Ewan J. McGhee, Ian Powley, Imran Ahmad, Marianna Kruithof-de Julio, George Thalmann, Ed Roberts, Carl S. Goodyear, Tamara Jamaspishvili, David M. Berman, Leo M. Carlin, John Le Quesne, Hing Y. Leung
Published 2021-07-01

An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism

by Marisa Nacke, Emma Sandilands, Konstantina Nikolatou, Álvaro Román-Fernández, Susan Mason, Rachana Patel, Sergio Lilla, Tamas Yelland, Laura C. A. Galbraith, Eva C. Freckmann, Lynn McGarry, Jennifer P. Morton, Emma Shanks, Hing Y. Leung, Elke Markert, Shehab Ismail, Sara Zanivan, Karen Blyth, David M. Bryant
Published 2021-03-01

Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

by Justine Bellier, Marie-Julie Nokin, Maurine Caprasse, Assia Tiamiou, Arnaud Blomme, Jean L. Scheijen, Benjamin Koopmansch, Gillian M. MacKay, Barbara Chiavarina, Brunella Costanza, Gilles Rademaker, Florence Durieux, Ferman Agirman, Naïma Maloujahmoum, Pino G. Cusumano, Pierre Lovinfosse, Hing Y. Leung, Frédéric Lambert, Vincent Bours, Casper G. Schalkwijk, Roland Hustinx, Olivier Peulen, Vincent Castronovo, Akeila Bellahcène
Published 2020-02-01

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

by Arnaud Blomme, Catriona A. Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E. Jamieson, Mélanie Planque, Grace H. McGregor, Paul Peixoto, Eric Hervouet, Colin Nixon, Mark Salji, Luke Gaughan, Elke Markert, Peter Repiscak, David Sumpton, Giovanny Rodriguez Blanco, Sergio Lilla, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Gillian M. MacKay, Sarah-Maria Fendt, Sara Zanivan, Hing Y. Leung
Published 2020-05-01