99 Structural optimization of anti-CEA-GITR-CAR to reduce tonic signaling and improve antigen-specific reactivity

by Hiroshi Shiku, Yizheng Wang, Linan Wang, Takuma Kato
Published 2020-11-01

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

by Naohiro Seo, Yoshitaka Shirakura, Yoshiro Tahara, Fumiyasu Momose, Naozumi Harada, Hiroaki Ikeda, Kazunari Akiyoshi, Hiroshi Shiku
Published 2018-01-01

Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induc...

by Mikiya Ishihara, Naohiro Seo, Jun Mitsui, Daisuke Muraoka, Maki Tanaka, Junichi Mineno, Hiroaki Ikeda, Hiroshi Shiku
Published 2014-01-01

Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.

by Fumiyasu Momose, Naohiro Seo, Yasushi Akahori, Shin-Ichi Sawada, Naozumi Harada, Toru Ogura, Kazunari Akiyoshi, Hiroshi Shiku
Published 2016-01-01

A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.

by Nicholas Paul Casey, Hiroshi Fujiwara, Kazushi Tanimoto, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa
Published 2016-01-01

A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression

by Sachiko Okamoto, Yasunori Amaishi, Yumi Goto, Hiroaki Ikeda, Hiroshi Fujiwara, Kiyotaka Kuzushima, Masaki Yasukawa, Hiroshi Shiku, Junichi Mineno
Published 2012-01-01

Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity.

by Hajime Kashima, Fumiyasu Momose, Hiroshi Umehara, Nao Miyoshi, Naohisa Ogo, Daisuke Muraoka, Hiroshi Shiku, Naozumi Harada, Akira Asai
Published 2016-01-01

MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours

by Mikiya Ishihara, Shinichi Kageyama, Yoshihiro Miyahara, Takeshi Ishikawa, Shugo Ueda, Norihito Soga, Hiroaki Naota, Katsumi Mukai, Naozumi Harada, Hiroaki Ikeda, Hiroshi Shiku
Published 2020-06-01

Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.

by Hiroaki Asai, Hiroshi Fujiwara, Jun An, Toshiki Ochi, Yukihiro Miyazaki, Kozo Nagai, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Hirofumi Inoue, Masaki Yasukawa
Published 2013-01-01

Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation.

by Kenichiro Nishikawa, Naohiro Seo, Mie Torii, Nei Ma, Daisuke Muraoka, Isao Tawara, Masahiro Masuya, Kyosuke Tanaka, Yoshiyuki Takei, Hiroshi Shiku, Naoyuki Katayama, Takuma Kato
Published 2014-01-01

First Case of Cytokine Release Syndrome after Nivolumab for Gastric Cancer

by Hiroyasu Oda, Mikiya Ishihara, Yoshihiro Miyahara, Junko Nakamura, Yuji Kozuka, Motoh Iwasa, Akira Tsunoda, Yoshiki Yamashita, Kanako Saito, Toshiro Mizuno, Hiroshi Shiku, Naoyuki Katayama
Published 2019-02-01

Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses.

by Kenshiro Tsuda, Keiichi Yamanaka, Wang Linan, Yoshihiro Miyahara, Tomoko Akeda, Takehisa Nakanishi, Hiroshi Kitagawa, Masato Kakeda, Ichiro Kurokawa, Hiroshi Shiku, Esteban C Gabazza, Hitoshi Mizutani
Published 2011-01-01

Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors

by Keisuke Fujii, Yoshihiro Miyahara, Naozumi Harada, Daisuke Muraoka, Mitsuhiro Komura, Rui Yamaguchi, Hideo Yagita, Junko Nakamura, Sahoko Sugino, Satoshi Okumura, Seiya Imoto, Satoru Miyano, Hiroshi Shiku
Published 2017-05-01

Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells

by Wenjie Gong, Lei Wang, Sophia Stock, Ming Ni, Maria-Luisa Schubert, Brigitte Neuber, Christian Kleist, Angela Hückelhoven-Krauss, Depei Wu, Carsten Müller-Tidow, Anita Schmitt, Hiroshi Shiku, Michael Schmitt, Leopold Sellner
Published 2021-01-01