CCR2+ migratory macrophages with M1 status are the early-responders in the cornea of HSV-1 infected mice.

by Dhong Hyun Lee, Ujjaldeep Jaggi, Homayon Ghiasi
Published 2019-01-01

Protocol for a mouse CNS demyelination model induced by a combination of HSV-1 and IL-2

by Satoshi Hirose, Kati Tormanen, Mihoko Kato, Jack Yu, Homayon Ghiasi
Published 2021-03-01

Role of Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein K (gK) Pathogenic CD8+ T Cells in Exacerbation of Eye Disease

by Ujjaldeep Jaggi, Shaohui Wang, Kati Tormanen, Harry Matundan, Alexander V. Ljubimov, Homayon Ghiasi
Published 2018-12-01

IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.

by Mandana Zandian, Kevin R Mott, Sariah J Allen, Shuang Chen, Moshe Arditi, Homayon Ghiasi
Published 2011-02-01

Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity.

by Sariah J Allen, Kevin R Mott, Yoshiharu Matsuura, Kohji Moriishi, Konstantin G Kousoulas, Homayon Ghiasi
Published 2014-01-01

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice.

by Dhong Hyun Lee, Mandana Zandian, Jane Kuo, Kevin R Mott, Shuang Chen, Moshe Arditi, Homayon Ghiasi
Published 2017-05-01

Increased phagocytosis in the presence of enhanced M2-like macrophage responses correlates with increased primary and latent HSV-1 infection.

by Ujjaldeep Jaggi, Mingjie Yang, Harry H Matundan, Satoshi Hirose, Prediman K Shah, Behrooz G Sharifi, Homayon Ghiasi
Published 2020-10-01

Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis

by Satoshi Hirose, Pedram Shafiei Jahani, Shaohui Wang, Ujjaldeep Jaggi, Kati Tormanen, Jack Yu, Mihoko Kato, Omid Akbari, Homayon Ghiasi
Published 2020-10-01

CD8α dendritic cells drive establishment of HSV-1 latency.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Bindu Konda, Behrooz G Sharifi, Clinton Jones, Steven L Wechsler, Terrence Town, Homayon Ghiasi
Published 2014-01-01

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi
Published 2014-01-01

A simple alkaline method for decellularizing human amniotic membrane for cell culture.

by Mehrnoosh Saghizadeh, Michael A Winkler, Andrei A Kramerov, David M Hemmati, Chantelle A Ghiam, Slobodan D Dimitrijevich, Dhruv Sareen, Loren Ornelas, Homayon Ghiasi, William J Brunken, Ezra Maguen, Yaron S Rabinowitz, Clive N Svendsen, Katerina Jirsova, Alexander V Ljubimov
Published 2013-01-01