IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.

by Mandana Zandian, Kevin R Mott, Sariah J Allen, Shuang Chen, Moshe Arditi, Homayon Ghiasi
Published 2011-02-01

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice.

by Dhong Hyun Lee, Mandana Zandian, Jane Kuo, Kevin R Mott, Shuang Chen, Moshe Arditi, Homayon Ghiasi
Published 2017-05-01

CD8α dendritic cells drive establishment of HSV-1 latency.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Bindu Konda, Behrooz G Sharifi, Clinton Jones, Steven L Wechsler, Terrence Town, Homayon Ghiasi
Published 2014-01-01

Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles

by Javier Mariscal, Tatyana Vagner, Minhyung Kim, Bo Zhou, Andrew Chin, Mandana Zandian, Michael R. Freeman, Sungyong You, Andries Zijlstra, Wei Yang, Dolores Di Vizio
Published 2020-01-01

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi
Published 2014-01-01

Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma

by Tatyana Vagner, Cristiana Spinelli, Valentina R. Minciacchi, Leonora Balaj, Mandana Zandian, Andrew Conley, Andries Zijlstra, Michael R. Freeman, Francesca Demichelis, Subhajyoti De, Edwin M. Posadas, Hisashi Tanaka, Dolores Di Vizio
Published 2018-12-01