Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy

by Simone Nüssing, Simone Nüssing, Joseph A. Trapani, Joseph A. Trapani, Ian A. Parish, Ian A. Parish
Published 2020-09-01

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen

by Mayura V. Wagle, Julia M. Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C. Goodnow, Ian A. Parish
Published 2018-07-01

A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control

by Gang Xin, David M. Schauder, Begoña Lainez, Jason S. Weinstein, Zhengxi Dai, Yuhong Chen, Enric Esplugues, Renren Wen, Demin Wang, Ian A. Parish, Allan J. Zajac, Joe Craft, Weiguo Cui
Published 2015-11-01

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

by Roybel R Ramiscal, Ian A Parish, Robert S Lee-Young, Jeffrey J Babon, Julianna Blagih, Alvin Pratama, Jaime Martin, Naomi Hawley, Jean Y Cappello, Pablo F Nieto, Julia I Ellyard, Nadia J Kershaw, Rebecca A Sweet, Christopher C Goodnow, Russell G Jones, Mark A Febbraio, Carola G Vinuesa, Vicki Athanasopoulos
Published 2015-10-01

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

by Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Junyun Lai, Amanda X. Y. Chen, Deborah Meyran, Kirsten L. Todd, Emma V. Petley, Sherly Mardiana, Christina Mølck, Gregory D. Stewart, Benjamin J. Solomon, Ian A. Parish, Paul J. Neeson, Simon J. Harrison, Lev M. Kats, Imran G. House, Phillip K. Darcy, Paul A. Beavis
Published 2021-05-01

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

by Mayura V. Wagle, Stephin J. Vervoort, Madison J. Kelly, Willem Van Der Byl, Timothy J. Peters, Ben P. Martin, Luciano G. Martelotto, Simone Nüssing, Kelly M. Ramsbottom, James R. Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A. Miosge, Debbie R. Howard, Renee Gloury, Sarah S. Gabriel, Daniel T. Utzschneider, Jane Oliaro, Jonathan D. Powell, Fabio Luciani, Joseph A. Trapani, Ricky W. Johnstone, Axel Kallies, Christopher C. Goodnow, Ian A. Parish
Published 2021-05-01