Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation

by Takashi Ito, Midori Kakuuchi, Ikuro Maruyama
Published 2021-03-01

Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice

by Takashi Ito, Takaaki Totoki, Seiya Takada, Shotaro Otsuka, Ikuro Maruyama
Published 2021-10-01

Specific detection of high mobility group box 1 degradation product with a novel ELISA

by Takaaki Totoki, Takashi Ito, Shingo Yamada, Goichi Honda, Tsuyoshi Hattori, Ikuro Maruyama
Published 2021-06-01

Overexpression of Receptor for Advanced Glycation End Products and High-Mobility Group Box 1 in Human Dental Pulp Inflammation

by Salunya Tancharoen, Tassanee Tengrungsun, Theeralaksna Suddhasthira, Kiyoshi Kikuchi, Nuttavun Vechvongvan, Masayuki Tokuda, Ikuro Maruyama
Published 2014-01-01

Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model.

by Kazuya Hosokawa, Tomoko Ohnishi, Hisayo Sameshima, Naoki Miura, Takehiko Koide, Ikuro Maruyama, Kenichi A Tanaka
Published 2014-01-01

Differential Regulation of Damage-Associated Molecular Pattern Release in a Mouse Model of Skeletal Muscle Ischemia/Reperfusion Injury

by Hiroaki Furubeppu, Takashi Ito, Midori Kakuuchi, Tomotsugu Yasuda, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Published 2021-07-01

A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia

by Bengo Atari, Takashi Ito, Tomoka Nagasato, Tomoko Ohnishi, Kazuya Hosokawa, Tomotsugu Yasuda, Ikuro Maruyama, Yasuyuki Kakihana
Published 2020-10-01

Serum histone H3 levels and platelet counts are potential markers for coagulopathy with high risk of death in septic patients: a single-center observational study

by Takashi Ito, Takaaki Totoki, Yayoi Yokoyama, Tomotsugu Yasuda, Hiroaki Furubeppu, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Published 2019-12-01

Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study

by Yayoi Yokoyama, Takashi Ito, Tomotsugu Yasuda, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Published 2019-01-01

Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care

by Kosaku Hatanaka, Takashi Ito, Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana
Published 2021-09-01

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

by Takashi Ito, Ikuro Maruyama, Shuji Shimazaki, Yasuhiro Yamamoto, Naoki Aikawa, Akio Hirayama, Goichi Honda, Hidehiko Saito
Published 2020-10-01

HMGB1 promotes the development of pulmonary arterial hypertension in rats.

by Yukari Sadamura-Takenaka, Takashi Ito, Satoshi Noma, Yoko Oyama, Shingo Yamada, Ko-ichi Kawahara, Hiromasa Inoue, Ikuro Maruyama
Published 2014-01-01

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

by Binita Shrestha, Binita Shrestha, Takashi Ito, Takashi Ito, Midori Kakuuchi, Takaaki Totoki, Tomoka Nagasato, Mika Yamamoto, Ikuro Maruyama
Published 2019-10-01

Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3

by Takashi Ito, Mayumi Nakahara, Yoshiki Masuda, Sachie Ono, Shingo Yamada, Hiroyasu Ishikura, Hitoshi Imaizumi, Chinatsu Kamikokuryo, Yasuyuki Kakihana, Ikuro Maruyama
Published 2018-11-01

Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke

by Eiichiro Tanaka, Yoshinaka Murai, Ikuro Maruyama, Ko-ichi Kawahara, Naoki Miura, Yoko Morimoto-Yamashita, Salunya Tancharoen, Takashi Ito, Kiyoshi Kikuchi
Published 2013-09-01

Correction: Kikuchi, K., et al., Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and...

by Kiyoshi Kikuchi, Salunya Tancharoen, Takashi Ito, Yoko Morimoto-Yamashita, Naoki Miura, Ko-ichi Kawahara, Ikuro Maruyama, Yoshinaka Murai, Eiichiro Tanaka
Published 2014-03-01

Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study

by Kiyoaki Yamamoto, Takashi Ito, Tomoka Nagasato, Atsushi Shinnakasu, Mihoko Kurano, Aiko Arimura, Hiroshi Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Ikuro Maruyama, Yoshihiko Nishio
Published 2019-09-01

Inhibition of HMGB1 Translocation by Green Tea Extract in Rats Exposed to Environmental Tobacco Smoke

by Sirintip Chaichalotornkul, Wisuda Suvitayavat, Vanida Sangalangkarn, Yuko Nawa, Kiyoshi Kikuchi, Koichi Kawahara, Tawee Saiwichai, Somphong Narkpinit, Pratap Singhasivanon, Ikuro Maruyama, Salunya Tancharoen
Published 2012-01-01

1,5-Anhydro-D-fructose Protects against Rotenone-Induced Neuronal Damage In Vitro through Mitochondrial Biogenesis

by Yuki Kasamo, Kiyoshi Kikuchi, Munekazu Yamakuchi, Shotaro Otsuka, Seiya Takada, Yuki Kambe, Takashi Ito, Ko-ichi Kawahara, Kazunori Arita, Koji Yoshimoto, Ikuro Maruyama
Published 2021-09-01

Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.

by Salunya Tancharoen, Takashi Matsuyama, Ko-Ichi Kawahara, Kenji Tanaka, Lyang-Ja Lee, Miho Machigashira, Kazuyuki Noguchi, Takashi Ito, Takahisa Imamura, Jan Potempa, Kiyoshi Kikuchi, Ikuro Maruyama
Published 2015-01-01