Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

by Sebastian I Arriola Apelo, Amy Lin, Jacqueline A Brinkman, Emma Meyer, Mark Morrison, Jay L Tomasiewicz, Cassidy P Pumper, Emma L Baar, Nicole E Richardson, Mohammed Alotaibi, Dudley W Lamming
Published 2020-07-01

Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

by Deyang Yu, Jay L. Tomasiewicz, Shany E. Yang, Blake R. Miller, Matthew H. Wakai, Dawn S. Sherman, Nicole E. Cummings, Emma L. Baar, Jacqueline A. Brinkman, Faizan A. Syed, Dudley W. Lamming
Published 2019-10-01

A novel rapamycin analog is highly selective for mTORC1 in vivo

by Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbajal, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedy, Dudley W. Lamming
Published 2019-07-01