Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

by Sebastian I Arriola Apelo, Amy Lin, Jacqueline A Brinkman, Emma Meyer, Mark Morrison, Jay L Tomasiewicz, Cassidy P Pumper, Emma L Baar, Nicole E Richardson, Mohammed Alotaibi, Dudley W Lamming
Published 2020-07-01

Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

by Deyang Yu, Jay L. Tomasiewicz, Shany E. Yang, Blake R. Miller, Matthew H. Wakai, Dawn S. Sherman, Nicole E. Cummings, Emma L. Baar, Jacqueline A. Brinkman, Faizan A. Syed, Dudley W. Lamming
Published 2019-10-01

A novel rapamycin analog is highly selective for mTORC1 in vivo

by Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbajal, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedy, Dudley W. Lamming
Published 2019-07-01

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

by Luigi Fontana, Nicole E. Cummings, Sebastian I. Arriola Apelo, Joshua C. Neuman, Ildiko Kasza, Brian A. Schmidt, Edda Cava, Francesco Spelta, Valeria Tosti, Faizan A. Syed, Emma L. Baar, Nicola Veronese, Sara E. Cottrell, Rachel J. Fenske, Beatrice Bertozzi, Harpreet K. Brar, Terri Pietka, Arnold D. Bullock, Robert S. Figenshau, Gerald L. Andriole, Matthew J. Merrins, Caroline M. Alexander, Michelle E. Kimple, Dudley W. Lamming
Published 2016-07-01