Botulinum Neurotoxins (BoNTs)—Antibody and Vaccine

by Jianlong Lou, James D. Marks
Published 2018-11-01

High throughput identification of monoclonal antibodies to membrane bound and secreted proteins using yeast and phage display.

by Lequn Zhao, Liang Qu, Jing Zhou, Zhengda Sun, Hao Zou, Yunn-Yi Chen, James D Marks, Yu Zhou
Published 2014-01-01

Combining anti-ERBB3 antibodies specific for domain I and domain III enhances the anti-tumor activity over the individual monoclonal antibodies.

by Jimson W D'Souza, Smitha Reddy, Lisa E Goldsmith, Irina Shchaveleva, James D Marks, Samuel Litwin, Matthew K Robinson
Published 2014-01-01

A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes.

by Yongfeng Fan, Consuelo Garcia-Rodriguez, Jianlong Lou, Weihua Wen, Fraser Conrad, Wenwu Zhai, Theresa J Smith, Leonard A Smith, James D Marks
Published 2017-01-01

Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats

by Yero Espinoza, David Wong, Ago Ahene, Kenneth Der, Zachary Martinez, John Pham, Ronald R. Cobb, Shauna Farr-Jones, James. D. Marks, Milan T. Tomic
Published 2019-06-01

Extraction of BoNT/A, /B, /E, and /F with a single, high affinity monoclonal antibody for detection of botulinum neurotoxin by Endopep-MS.

by Suzanne R Kalb, Consuelo Garcia-Rodriguez, Jianlong Lou, Jakub Baudys, Theresa J Smith, James D Marks, Leonard A Smith, James L Pirkle, John R Barr
Published 2010-08-01

Extraction and inhibition of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 by a panel of monoclonal anti-BoNT/A antibodies.

by Suzanne R Kalb, Jianlong Lou, Consuelo Garcia-Rodriguez, Isin N Geren, Theresa J Smith, Hercules Moura, James D Marks, Leonard A Smith, James L Pirkle, John R Barr
Published 2009-01-01

Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor

by Noah Federman, Jason Chan, Jon O. Nagy, Elliot M. Landaw, Katelyn McCabe, Anna M. Wu, Timothy Triche, HyungGyoo Kang, Bin Liu, James D. Marks, Christopher T. Denny
Published 2012-01-01

Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model

by Milan T. Tomic, Shauna Farr-Jones, Emily S. Syar, Nancy Niemuth, Dean Kobs, Michael J. Hackett, Yero Espinoza, Zacchary Martinez, Khanh Pham, Doris M. Snow, James D. Marks, Ronald R. Cobb
Published 2021-09-01

Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids.

by Theresa J Smith, Karen K Hill, Brian T Foley, John C Detter, A Christine Munk, David C Bruce, Norman A Doggett, Leonard A Smith, James D Marks, Gary Xie, Thomas S Brettin
Published 2007-12-01

Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity.

by Yongfeng Fan, Isin N Geren, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Theresa J Smith, Leonard A Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A Wilson, James D Marks
Published 2015-01-01

A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model

by Doris M. Snow, Ronald R. Cobb, Juan Martinez, Isaac Finger-Baker, Laura Collins, Sara Terpening, Emily S. Syar, Nancy Niemuth, Dean Kobs, Roy Barnewall, Shauna Farr-Jones, James D. Marks, Milan T. Tomic
Published 2021-01-01

Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model

by Milan T. Tomic, Yero Espinoza, Zachary Martinez, Khanh Pham, Ronald R. Cobb, Doris M. Snow, Christopher G. Earnhart, Traci Pals, Emily S. Syar, Nancy Niemuth, Dean J. Kobs, Shauna Farr-Jones, James D. Marks
Published 2019-04-01

Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B

by Yongfeng Fan, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Isin N. Geren, Consuelo Garcia-Rodriguez, Theresa J. Smith, Leonard A. Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A. Wilson, James D. Marks
Published 2015-08-01

A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes

by Consuelo Garcia-Rodriguez, Ali Razai, Isin N. Geren, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Published 2018-03-01

A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A

by Jianlong Lou, Weihua Wen, Fraser Conrad, Qi Meng, Jianbo Dong, Zhengda Sun, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, Luisa W. Cheng, Thomas D. Henderson, Jennifer L. Brown, Theresa J. Smith, Leonard A. Smith, Anthony Cormier, James D. Marks
Published 2018-02-01

A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D

by Consuelo Garcia-Rodriguez, Shude Yan, Isin N. Geren, Kristeene A. Knopp, Jianbo Dong, Zhengda Sun, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Published 2021-09-01

Targeting EphA2 in Bladder Cancer Using a Novel Antibody-Directed Nanotherapeutic

by Walid Kamoun, Elden Swindell, Christine Pien, Lia Luus, Jason Cain, Minh Pham, Irawati Kandela, Zhaohua Richard Huang, Suresh K. Tipparaju, Alexander Koshkaryev, Vasileios Askoxylakis, Dmitri B. Kirpotin, Troy Bloom, Mari Mino-Kenudson, James D. Marks, Alena Zalutskaya, Wiam Bshara, Carl Morrison, Daryl C. Drummond
Published 2020-10-01