A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.

by Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Teresa Mulet, Joaquín Rullas, Esperanza Herreros, Santiago Ferrer, Elena Jiménez, Alfonso Mendoza, Javier Regadera, Philip J Rosenthal, Ian Bathurst, David L Pompliano, Federico Gómez de las Heras, Domingo Gargallo-Viola
Published 2008-01-01

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.

by Giovanna Poce, Robert H Bates, Salvatore Alfonso, Martina Cocozza, Giulio Cesare Porretta, Lluís Ballell, Joaquin Rullas, Fátima Ortega, Alessandro De Logu, Emanuela Agus, Valentina La Rosa, Maria Rosalia Pasca, Edda De Rossi, Baojie Wae, Scott G Franzblau, Fabrizio Manetti, Maurizio Botta, Mariangela Biava
Published 2013-01-01

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tub...

by Modesto J Remuiñán, Esther Pérez-Herrán, Joaquín Rullás, Carlos Alemparte, María Martínez-Hoyos, David J Dow, Johnson Afari, Nalini Mehta, Jorge Esquivias, Elena Jiménez, Fátima Ortega-Muro, María Teresa Fraile-Gabaldón, Vickey L Spivey, Nicholas J Loman, Mark J Pallen, Chrystala Constantinidou, Douglas J Minick, Mónica Cacho, María José Rebollo-López, Carolina González, Verónica Sousa, Iñigo Angulo-Barturen, Alfonso Mendoza-Losana, David Barros, Gurdyal S Besra, Lluís Ballell, Nicholas Cammack
Published 2013-01-01

Identification of KasA as the cellular target of an anti-tubercular scaffold

by Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
Published 2016-09-01

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

by María Martínez-Hoyos, Esther Perez-Herran, Gulcin Gulten, Lourdes Encinas, Daniel Álvarez-Gómez, Emilio Alvarez, Santiago Ferrer-Bazaga, Adolfo García-Pérez, Fátima Ortega, Iñigo Angulo-Barturen, Joaquin Rullas-Trincado, Delia Blanco Ruano, Pedro Torres, Pablo Castañeda, Sophie Huss, Raquel Fernández Menéndez, Silvia González del Valle, Lluis Ballell, David Barros, Sundip Modha, Neeraj Dhar, François Signorino-Gelo, John D. McKinney, Jose Francisco García-Bustos, Jose Luis Lavandera, James C. Sacchettini, M. Soledad Jimenez, Nuria Martín-Casabona, Julia Castro-Pichel, Alfonso Mendoza-Losana
Published 2016-06-01