Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183

by Katherine A. Abrahams, Wei Hu, Gang Li, Yu Lu, Emily J. Richardson, Nicholas J. Loman, Haihong Huang, Gurdyal S. Besra
Published 2020-12-01

Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation.

by Grace Mugumbate, Katherine A Abrahams, Jonathan A G Cox, George Papadatos, Gerard van Westen, Joël Lelièvre, Szymon T Calus, Nicholas J Loman, Lluis Ballell, David Barros, John P Overington, Gurdyal S Besra
Published 2015-01-01

Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB.

by Katherine A Abrahams, Jonathan A G Cox, Vickey L Spivey, Nicholas J Loman, Mark J Pallen, Chrystala Constantinidou, Raquel Fernández, Carlos Alemparte, Modesto J Remuiñán, David Barros, Lluis Ballell, Gurdyal S Besra
Published 2012-01-01

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.

by Sudagar S Gurcha, Veeraraghavan Usha, Jonathan A G Cox, Klaus Fütterer, Katherine A Abrahams, Apoorva Bhatt, Luke J Alderwick, Robert C Reynolds, Nicholas J Loman, VijayaShankar Nataraj, Carlos Alemparte, David Barros, Adrian J Lloyd, Lluis Ballell, Judith V Hobrath, Gurdyal S Besra
Published 2014-01-01

Identification of KasA as the cellular target of an anti-tubercular scaffold

by Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
Published 2016-09-01