Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy

by Ilse A. E. Bollen, Marijke van der Meulen, Kyra de Goede, Diederik W. D. Kuster, Michiel Dalinghaus, Jolanda van der Velden, Jolanda van der Velden
Published 2017-12-01

Glycolaldehyde-Derived High-Molecular-Weight Advanced Glycation End-Products Induce Cardiac Dysfunction through Structural and Functional Remodeling of Cardiomyocytes

by Dorien Deluyker, Lize Evens, Sibren Haesen, Ronald B. Driesen, Diederik Kuster, Maxim Verboven, Hanne Beliën, Jolanda van der Velden, Ivo Lambrichts, Virginie Bito
Published 2020-08-01

Extracellular SPARC increases cardiomyocyte contraction during health and disease.

by Sophie Deckx, Daniel M Johnson, Marieke Rienks, Paolo Carai, Elza Van Deel, Jolanda Van der Velden, Karin R Sipido, Stephane Heymans, Anna-Pia Papageorgiou
Published 2019-01-01

Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation

by Thomas L. Lynch, Mayandi Sivaguru, Murugesan Velayutham, Arturo J. Cardounel, Michelle Michels, David Barefield, Suresh Govindan, Cristobal dos Remedios, Jolanda van der Velden, Sakthivel Sadayappan
Published 2015-01-01

Large-Scale Contractility Measurements Reveal Large Atrioventricular and Subtle Interventricular Differences in Cultured Unloaded Rat Cardiomyocytes

by Edgar E. Nollet, Emmy M. Manders, Max Goebel, Valentijn Jansen, Cord Brockmann, Jorrit Osinga, Jolanda van der Velden, Michiel Helmes, Michiel Helmes, Diederik W. D. Kuster
Published 2020-07-01

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

by James W McNamara, Amy Li, Sean Lal, J Martijn Bos, Samantha P Harris, Jolanda van der Velden, Michael J Ackerman, Roger Cooke, Cristobal G Dos Remedios
Published 2017-01-01

Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy.

by Louise L A M Nijenkamp, Ilse A E Bollen, Hans W M Niessen, Cris G Dos Remedios, Michelle Michels, Corrado Poggesi, Carolyn Y Ho, Diederik W D Kuster, Jolanda van der Velden
Published 2020-01-01

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

by Larissa M. Dorsch, Maike Schuldt, Cristobal G. dos Remedios, Arend F. L. Schinkel, Peter L. de Jong, Michelle Michels, Diederik W. D. Kuster, Bianca J. J. M. Brundel, Jolanda van der Velden
Published 2019-07-01

Metabolomics in Severe Aortic Stenosis Reveals Intermediates of Nitric Oxide Synthesis as Most Distinctive Markers

by Beau Olivier van Driel, Maike Schuldt, Sila Algül, Evgeni Levin, Ahmet Güclü, Tjeerd Germans, Albert C. van Rossum, Jiayi Pei, Magdalena Harakalova, Annette Baas, Judith J. M. Jans, Jolanda van der Velden
Published 2021-03-01

Sex-Related Differences in Protein Expression in Sarcomere Mutation-Positive Hypertrophic Cardiomyopathy

by Maike Schuldt, Larissa M. Dorsch, Jaco C. Knol, Thang V. Pham, Tim Schelfhorst, Sander R. Piersma, Cris dos Remedios, Cris dos Remedios, Michelle Michels, Connie R. Jimenez, Diederik W. D. Kuster, Jolanda van der Velden
Published 2021-03-01

Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart.

by Willemijn van Eldik, Brigit den Adel, Jantine Monshouwer-Kloots, Daniela Salvatori, Saskia Maas, Ingeborg van der Made, Esther E Creemers, Derk Frank, Norbert Frey, Nicky Boontje, Jolanda van der Velden, Paul Steendijk, Christine Mummery, Robert Passier, Abdelaziz Beqqali
Published 2017-01-01

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.

by Viola Kooij, Pingbo Zhang, Sander R Piersma, Vasco Sequeira, Nicky M Boontje, Paul J M Wijnker, Connie R Jiménez, Kornelia E Jaquet, Cris dos Remedios, Anne M Murphy, Jennifer E Van Eyk, Jolanda van der Velden, Ger Jm Stienen
Published 2013-01-01

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy

by Judith Montag, Kathrin Kowalski, Mirza Makul, Pia Ernstberger, Ante Radocaj, Julia Beck, Edgar Becker, Snigdha Tripathi, Britta Keyser, Christian Mühlfeld, Kirsten Wissel, Andreas Pich, Jolanda van der Velden, Cristobal G. dos Remedios, Andreas Perrot, Antonio Francino, Francesco Navarro-López, Bernhard Brenner, Theresia Kraft
Published 2018-04-01

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

by Rio P. Juni, PhD, Diederik W.D. Kuster, PhD, Max Goebel, MSc, Michiel Helmes, PhD, René J.P. Musters, PhD, Jolanda van der Velden, PhD, Pieter Koolwijk, PhD, Walter J. Paulus, MD, PhD, Victor W.M. van Hinsbergh, PhD
Published 2019-09-01

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

by Renee G.C. Maas, Soah Lee, Magdalena Harakalova, Christian J.B. Snijders Blok, William R. Goodyer, Jesper Hjortnaes, Pieter A.F.M. Doevendans, Linda W. Van Laake, Jolanda van der Velden, Folkert W. Asselbergs, Joseph C. Wu, Joost P.G. Sluijter, Sean M. Wu, Jan W. Buikema
Published 2021-03-01

miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a

by Zhiyong Lei, Zhiyong Lei, Christine Wahlquist, Hamid el Azzouzi, Janine C. Deddens, Diederik Kuster, Alain van Mil, Alain van Mil, Agustin Rojas-Munoz, Manon M. Huibers, Mark Mercola, Roel de Weger, Jolanda Van der Velden, Junjie Xiao, Junjie Xiao, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Joost P. G. Sluijter, Joost P. G. Sluijter
Published 2021-03-01

Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

by Thomas L. Lynch, IVPhD, Diederik W.D. Kuster, PhD, Beverly Gonzalez, ScM, Neelam Balasubramanian, BA, Nandini Nair MD, PhD, Sharlene Day, PhD, Jenna E. Calvino, BA, Yanli Tan, RN, Christoph Liebetrau, MD, Christian Troidl, PhD, Christian W. Hamm, MD, Ahmet Güçlü, MD, Barbara McDonough, RN, Ali J. Marian, MD, Jolanda van der Velden, PhD, Christine E. Seidman, MD, Gordon S. Huggins, MD, Sakthivel Sadayappan, PhD
Published 2017-04-01