Tie2 as a novel key factor of microangiopathy in systemic sclerosis

by Falk Moritz, Janine Schniering, Jörg H. W. Distler, Renate E. Gay, Steffen Gay, Oliver Distler, Britta Maurer
Published 2017-05-01

Case report of severe constrictive perimyocarditis and ischemic hepatitis in a Crohn’s disease patient upon infliximab-induced lupus-like syndrome

by Simon Hirschmann, Sarah Fischer, Entcho Klenske, Katharina Dechant, Jörg H.W. Distler, Christoph Treutlein, Markus F. Neurath, Raja Atreya
Published 2021-09-01

Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis

by Laura Duffy, John Henderson, Max Brown, Stefan Pryzborski, Nicola Fullard, Lena Summa, Jorg H. W. Distler, Richard Stratton, Steven O’Reilly
Published 2021-06-01

An open-label study to evaluate biomarkers and safety in systemic sclerosis patients treated with paquinimod

by Roger Hesselstrand, Jörg H. W. Distler, Gabriela Riemekasten, Dirk M. Wuttge, Marie Törngren, Helén C. Nyhlén, Fredrik Andersson, Helena Eriksson, Birgitta Sparre, Helén Tuvesson, Oliver Distler
Published 2021-07-01

Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

by Hana Štorkánová, Sabína Oreská, Maja Špiritović, Barbora Heřmánková, Kristýna Bubová, Martin Komarc, Karel Pavelka, Jiří Vencovský, Jörg H. W. Distler, Ladislav Šenolt, Radim Bečvář, Michal Tomčík
Published 2021-01-01

Small Molecule Tyrosine Kinase Inhibitor Nintedanib Reduces Development of Cardiac Allograft Vasculopathy in Murine Aortic Allografts

by Annika Gocht, Bernd Spriewald, MD, DPhil, Jörg H.W. Distler, MD, Martina Ramsperger-Gleixner, PhD, Stephan M. Ensminger, MD, DPhil, Michael Weyand, MD, Christian Heim, MD
Published 2018-07-01

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development

by Florian Renoux, Mara Stellato, Claudia Haftmann, Alexander Vogetseder, Riyun Huang, Arun Subramaniam, Mike O. Becker, Przemyslaw Blyszczuk, Burkhard Becher, Jörg H.W. Distler, Gabriela Kania, Onur Boyman, Oliver Distler
Published 2020-06-01

Inhibition of Hsp90 Counteracts the Established Experimental Dermal Fibrosis Induced by Bleomycin

by Hana Štorkánová, Lenka Štorkánová, Adéla Navrátilová, Viktor Bečvář, Hana Hulejová, Sabína Oreská, Barbora Heřmánková, Maja Špiritović, Radim Bečvář, Karel Pavelka, Jiří Vencovský, Jörg H. W. Distler, Ladislav Šenolt, Michal Tomčík
Published 2021-06-01

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

by Debomita Chakraborty, Barbora Šumová, Tatjana Mallano, Chih-Wei Chen, Alfiya Distler, Christina Bergmann, Ingo Ludolph, Raymund E. Horch, Kolja Gelse, Andreas Ramming, Oliver Distler, Georg Schett, Ladislav Šenolt, Jörg H. W. Distler
Published 2017-10-01

Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics

by Stevan D. Stojanović, Maximilian Fuchs, Chunguang Liang, Kevin Schmidt, Ke Xiao, Annette Just, Angelika Pfanne, Andreas Pich, Gregor Warnecke, Peter Braubach, Christina Petzold, Danny Jonigk, Jörg H. W. Distler, Jan Fiedler, Thomas Thum, Meik Kunz
Published 2021-06-01

Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus

by Mona H. C. Biermann, Sebastian Boeltz, Elmar Pieterse, Jasmin Knopf, Jürgen Rech, Rostyslav Bilyy, Rostyslav Bilyy, Johan van der Vlag, Angela Tincani, Jörg H. W. Distler, Gerhard Krönke, Georg Andreas Schett, Martin Herrmann, Luis E. Muñoz
Published 2018-05-01

Incidences and Risk Factors of Organ Manifestations in the Early Course of Systemic Sclerosis: A Longitudinal EUSTAR Study.

by Veronika K Jaeger, Elina G Wirz, Yannick Allanore, Philipp Rossbach, Gabriela Riemekasten, Eric Hachulla, Oliver Distler, Paolo Airò, Patricia E Carreira, Alexandra Balbir Gurman, Mohammed Tikly, Serena Vettori, Nemanja Damjanov, Ulf Müller-Ladner, Jörg H W Distler, Mangtao Li, Ulrich A Walker, EUSTAR co-authors
Published 2016-01-01

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

by Ariella Zehender, Jingang Huang, Andrea-Hermina Györfi, Alexandru-Emil Matei, Thuong Trinh-Minh, Xiaohan Xu, Yi-Nan Li, Chih-Wei Chen, Jianping Lin, Clara Dees, Christian Beyer, Kolja Gelse, Zhong-Yin Zhang, Christina Bergmann, Andreas Ramming, Walter Birchmeier, Oliver Distler, Georg Schett, Jörg H. W. Distler
Published 2018-08-01

TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

by Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nüchel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Györfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Jörg H. W. Distler
Published 2021-07-01

Accuracy, patient-perceived usability, and acceptance of two symptom checkers (Ada and Rheport) in rheumatology: interim results from a randomized controlled crossover trial

by Johannes Knitza, Jacob Mohn, Christina Bergmann, Eleni Kampylafka, Melanie Hagen, Daniela Bohr, Harriet Morf, Elizabeth Araujo, Matthias Englbrecht, David Simon, Arnd Kleyer, Timo Meinderink, Wolfgang Vorbrüggen, Cay Benedikt von der Decken, Stefan Kleinert, Andreas Ramming, Jörg H. W. Distler, Nicolas Vuillerme, Achim Fricker, Peter Bartz-Bazzanella, Georg Schett, Axel J. Hueber, Martin Welcker
Published 2021-04-01

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

by F David Carmona, Jose-Ezequiel Martin, Lorenzo Beretta, Carmen P Simeón, Patricia E Carreira, José Luis Callejas, Mónica Fernández-Castro, Luis Sáez-Comet, Emma Beltrán, María Teresa Camps, María Victoria Egurbide, Spanish Scleroderma Group, Paolo Airó, Raffaella Scorza, Claudio Lunardi, Nicolas Hunzelmann, Gabriela Riemekasten, Torsten Witte, Alexander Kreuter, Jörg H W Distler, Rajan Madhok, Paul Shiels, Jacob M van Laar, Carmen Fonseca, Christopher Denton, Ariane Herrick, Jane Worthington, Annemie J Schuerwegh, Madelon C Vonk, Alexandre E Voskuyl, Timothy R D J Radstake, Javier Martín
Published 2013-01-01

Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.

by Yannick Allanore, Mohamad Saad, Philippe Dieudé, Jérôme Avouac, Jorg H W Distler, Philippe Amouyel, Marco Matucci-Cerinic, Gabriella Riemekasten, Paolo Airo, Inga Melchers, Eric Hachulla, Daniele Cusi, H-Erich Wichmann, Julien Wipff, Jean-Charles Lambert, Nicolas Hunzelmann, Kiet Tiev, Paola Caramaschi, Elisabeth Diot, Otylia Kowal-Bielecka, Gabriele Valentini, Luc Mouthon, László Czirják, Nemanja Damjanov, Erika Salvi, Costanza Conti, Martina Müller, Ulf Müller-Ladner, Valeria Riccieri, Barbara Ruiz, Jean-Luc Cracowski, Luc Letenneur, Anne Marie Dupuy, Oliver Meyer, André Kahan, Arnold Munnich, Catherine Boileau, Maria Martinez
Published 2011-07-01

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

by Elena López-Isac, Marialbert Acosta-Herrera, Martin Kerick, Shervin Assassi, Ansuman T. Satpathy, Jeffrey Granja, Maxwell R. Mumbach, Lorenzo Beretta, Carmen P. Simeón, Patricia Carreira, Norberto Ortego-Centeno, Ivan Castellvi, Lara Bossini-Castillo, F. David Carmona, Gisela Orozco, Nicolas Hunzelmann, Jörg H. W. Distler, Andre Franke, Claudio Lunardi, Gianluca Moroncini, Armando Gabrielli, Jeska de Vries-Bouwstra, Cisca Wijmenga, Bobby P. C. Koeleman, Annika Nordin, Leonid Padyukov, Anna-Maria Hoffmann-Vold, Benedicte Lie, European Scleroderma Group†, Susanna Proudman, Wendy Stevens, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), Timothy Vyse, Ariane L. Herrick, Jane Worthington, Christopher P. Denton, Yannick Allanore, Matthew A. Brown, Timothy R. D. J. Radstake, Carmen Fonseca, Howard Y. Chang, Maureen D. Mayes, Javier Martin
Published 2019-10-01