Correction: First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent.

by Joshua E Allen, Roslyn N Crowder, Wafik S El-Deiry
Published 2016-01-01

First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent.

by Joshua E Allen, Roslyn N Crowder, Wafik S El-Deiry
Published 2015-01-01

Correction: The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer

by Joshua E. Allen, Jean-Nicolas Gallant, David T. Dicker, Shantu Amin, Rosalyn B. Irby, Arun K. Sharma, Wafik S. El-Deiry
Published 2013-01-01

The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer.

by Joshua E Allen, Jean-Nicolas Gallant, David T Dicker, Shantu Amin, Rosalyn B Irby, Arun K Sharma, Wafik S El-Deiry
Published 2013-01-01

Correction: The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer.

by Joshua E. Allen, Jean-Nicolas Gallant, David T. Dicker, Shantu Amin, Rosalyn B. Irby, Arun K. Sharma, Wafik S. El-Deiry
Published 2013-01-01

A Bayesian machine learning approach for drug target identification using diverse data types

by Neel S. Madhukar, Prashant K. Khade, Linda Huang, Kaitlyn Gayvert, Giuseppe Galletti, Martin Stogniew, Joshua E. Allen, Paraskevi Giannakakou, Olivier Elemento
Published 2019-11-01

Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl1 axis.

by Junaid Abdulghani, Joshua E Allen, David T Dicker, Yingqiu Yvette Liu, David Goldenberg, Charles D Smith, Robin Humphreys, Wafik S El-Deiry
Published 2013-01-01

Role of Dopamine Receptors in the Anticancer Activity of ONC201

by Christina Leah B. Kline, Marie D. Ralff, Amriti R. Lulla, Jessica M. Wagner, Phillip H. Abbosh, David T. Dicker, Joshua E. Allen, Wafik S. El-Deiry
Published 2018-01-01

The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma

by Yong-sheng Tu, Jin He, Huan Liu, Hans C. Lee, Hua Wang, Jo Ishizawa, Joshua E. Allen, Michael Andreeff, Robert Z. Orlowski, Richard E. Davis, Jing Yang
Published 2017-10-01

Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

by Francesca Amoroso, Kimberley Glass, Reema Singh, Francisco Liberal, Rebecca E. Steele, Sarah Maguire, Rohinton Tarapore, Joshua E. Allen, Sandra Van Schaeybroeck, Karl T. Butterworth, Kevin Prise, Joe M. O’Sullivan, Suneil Jain, David J. Waugh, Ian G. Mills
Published 2021-02-01

Correction: Hu, W., et al. Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype. <i>Cancers</i> 2020, <i>12</i>, 2436

by Wen Hu, Li Zhang, Sammy Ferri-Borgogno, Suet-Ying Kwan, Kelsey E. Lewis, Han T. Cun, Tsz-Lun Yeung, Pamela T. Soliman, Rohinton S. Tarapore, Joshua E. Allen, Xinyuan Guan, Karen H. Lu, Samuel C. Mok, Chi-Lam Au-Yeung
Published 2021-02-01

Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype

by Wen Hu, Li Zhang, Sammy Ferri-Borgogno, Suet-Ying Kwan, Kelsey E. Lewis, Han T. Cun, Tsz-Lun Yeung, Pamela T. Soliman, Rohinton S. Tarapore, Joshua E. Allen, Xinyuan Guan, Karen H. Lu, Samuel C. Mok, Chi-Lam Au-Yeung
Published 2020-08-01

ONC206, an Imipridone Derivative, Induces Cell Death Through Activation of the Integrated Stress Response in Serous Endometrial Cancer In Vitro

by Yingao Zhang, Yingao Zhang, Yu Huang, Yu Huang, Yajie Yin, Yali Fan, Yali Fan, Wenchuan Sun, Xiaoling Zhao, Xiaoling Zhao, Katherine Tucker, Allison Staley, Sarah Paraghamian, Gabrielle Hawkins, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou, Chunxiao Zhou, Victoria Bae-Jump, Victoria Bae-Jump
Published 2020-10-01

Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer

by Stuart R. Pierce, Ziwei Fang, Yajie Yin, Lindsay West, Majdouline Asher, Tianran Hao, Xin Zhang, Katherine Tucker, Allison Staley, Yali Fan, Wenchuan Sun, Dominic T. Moore, Chang Xu, Yi-Hsuan Tsai, Joel Parker, Varun Vijay Prabhu, Joshua E. Allen, Douglas Lee, Chunxiao Zhou, Victoria Bae-Jump
Published 2021-02-01

Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors.

by Varun V Prabhu, Amriti R Lulla, Neel S Madhukar, Marie D Ralff, Dan Zhao, Christina Leah B Kline, A Pieter J Van den Heuvel, Avital Lev, Mathew J Garnett, Ultan McDermott, Cyril H Benes, Tracy T Batchelor, Andrew S Chi, Olivier Elemento, Joshua E Allen, Wafik S El-Deiry
Published 2017-01-01

ONC201 and imipridones: Anti-cancer compounds with clinical efficacy

by Varun Vijay Prabhu, Sara Morrow, Abed Rahman Kawakibi, Lanlan Zhou, Marie Ralff, Jocelyn Ray, Aakash Jhaveri, Isacco Ferrarini, Young Lee, Cassandra Parker, Yiqun Zhang, Robyn Borsuk, Wen-I Chang, Joshua N. Honeyman, Fabio Tavora, Benedito Carneiro, Alexander Raufi, Kelsey Huntington, Lindsey Carlsen, Anna Louie, Howard Safran, Attila A. Seyhan, Rohinton S. Tarapore, Lee Schalop, Martin Stogniew, Joshua E. Allen, Wolfgang Oster, Wafik S. El-Deiry
Published 2020-12-01

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration

by Mark N. Stein, Jyoti Malhotra, Rohinton S. Tarapore, Usha Malhotra, Ann W. Silk, Nancy Chan, Lorna Rodriguez, Joseph Aisner, Robert D. Aiken, Tina Mayer, Bruce G. Haffty, Jenna H. Newman, Salvatore M. Aspromonte, Praveen K. Bommareddy, Ricardo Estupinian, Charles B. Chesson, Evita T. Sadimin, Shengguo Li, Daniel J. Medina, Tracie Saunders, Melissa Frankel, Aparna Kareddula, Sherrie Damare, Elayne Wesolowsky, Christian Gabel, Wafik S. El-Deiry, Varun V. Prabhu, Joshua E. Allen, Martin Stogniew, Wolfgang Oster, Joseph R. Bertino, Steven K. Libutti, Janice M. Mehnert, Andrew Zloza
Published 2019-05-01