Deficiency in CCR2 increases susceptibility of mice to infection with an intracellular pathogen, Francisella tularensis LVS, but does not impair development of protective immunity.

by Sherry L Kurtz, Roberto De Pascalis, Anda I Meierovics, Karen L Elkins
Published 2021-01-01

Francisella tularensis Vaccines Elicit Concurrent Protective T- and B-Cell Immune Responses in BALB/cByJ Mice.

by Roberto De Pascalis, Lara Mittereder, Alicia Y Chou, Nikki J Kennett, Karen L Elkins
Published 2015-01-01

IL-23 p19 knockout mice exhibit minimal defects in responses to primary and secondary infection with Francisella tularensis LVS.

by Sherry L Kurtz, Alicia Y Chou, Klara Kubelkova, Daniel J Cua, Karen L Elkins
Published 2014-01-01

The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection

by Sherry L. Kurtz, Amy P. Rossi, Gillian L. Beamer, Dan M. Gatti, Igor Kramnik, Karen L. Elkins
Published 2020-04-01

Production of IFN-γ by splenic dendritic cells during innate immune responses against Francisella tularensis LVS depends on MyD88, but not TLR2, TLR4, or TLR9.

by Roberto De Pascalis, Amy P Rossi, Lara Mittereder, Kazuyo Takeda, Adovi Akue, Sherry L Kurtz, Karen L Elkins
Published 2020-01-01

Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS.

by Roberto De Pascalis, Alicia Y Chou, Catharine M Bosio, Chiung-Yu Huang, Dean A Follmann, Karen L Elkins
Published 2012-01-01

Modern Development and Production of a New Live Attenuated Bacterial Vaccine, SCHU S4 <i>ΔclpB</i>, to Prevent Tularemia

by J. Wayne Conlan, Anders Sjöstedt, H. Carl Gelhaus, Perry Fleming, Kevan McRae, Ronald R. Cobb, Roberto De Pascalis, Karen L. Elkins
Published 2021-06-01

A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis.

by Roberto De Pascalis, Andrew Hahn, Helen M Brook, Patrik Ryden, Nathaniel Donart, Lara Mittereder, Blake Frey, Terry H Wu, Karen L Elkins
Published 2018-01-01