Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist

by Sofia R Gameiro, Karin M Knudson, Kristin C Hicks, Yohei Ozawa
Published 2020-06-01

Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy

by Karin M. Knudson, Kristin C. Hicks, Sarah Alter, Jeffrey Schlom, Sofia R. Gameiro
Published 2019-03-01

Low-Affinity T Cells Are Programmed to Maintain Normal Primary Responses but Are Impaired in Their Recall to Low-Affinity Ligands

by Karin M. Knudson, Nicholas P. Goplen, Cody A. Cunningham, Mark A. Daniels, Emma Teixeiro
Published 2013-08-01

Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa

by Yohei Ozawa, Kristin C. Hicks, Christine M. Minnar, Karin M. Knudson, Jeffrey Schlom, Sofia R. Gameiro
Published 2021-01-01

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

by Karin M. Knudson, Kristin C. Hicks, Xiaoling Luo, Jin-Qiu Chen, Jeffrey Schlom, Sofia R. Gameiro
Published 2018-05-01

Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape

by Kristin C. Hicks, Paul L. Chariou, Yohei Ozawa, Christine M. Minnar, Karin M. Knudson, Thomas J. Meyer, Jing Bian, Margaret Cam, Jeffrey Schlom, Sofia R. Gameiro
Published 2021-08-01

Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types

by Kristin C. Hicks, Massimo Fantini, Renee N. Donahue, Angie Schwab, Karin M. Knudson, Sarah R. Tritsch, Caroline Jochems, Paul E. Clavijo, Clint T. Allen, James W. Hodge, Kwong Y. Tsang, Jeffrey Schlom, Sofia R. Gameiro
Published 2018-11-01

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

by Caroline Jochems, Sarah R. Tritsch, Karin M. Knudson, Sofia R. Gameiro, Claire Smalley Rumfield, Samuel T. Pellom, Y. Maurice Morillon, Robby Newman, Warren Marcus, Christopher Szeto, Shahrooz Rabizadeh, Hing C. Wong, Patrick Soon-Shiong, Jeffrey Schlom
Published 2019-02-01

Improving the Odds in Advanced Breast Cancer With Combination Immunotherapy: Stepwise Addition of Vaccine, Immune Checkpoint Inhibitor, Chemotherapy, and HDAC Inhibitor in Advanced...

by Margaret E. Gatti-Mays, Sofia R. Gameiro, Yohei Ozawa, Karin M. Knudson, Kristin C. Hicks, Claudia Palena, Lisa M. Cordes, Seth M. Steinberg, Deneise Francis, Fatima Karzai, Stanley Lipkowitz, Renee N. Donahue, Caroline Jochems, Jeffrey Schlom, James L. Gulley
Published 2021-03-01