Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state

by Agata Butryn, Stephan Woike, Savera J Shetty, David T Auble, Karl-Peter Hopfner
Published 2018-10-01

Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

by Charlotte Lässig, Katja Lammens, Jacob Lucián Gorenflos López, Sebastian Michalski, Olga Fettscher, Karl-Peter Hopfner
Published 2018-07-01

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1

by Agata Butryn, Jan M Schuller, Gabriele Stoehr, Petra Runge-Wollmann, Friedrich Förster, David T Auble, Karl-Peter Hopfner
Published 2015-08-01

Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding.

by Alfred Lammens, Monika Baehner, Ulrich Kohnert, Jens Niewoehner, Leopold von Proff, Michael Schraeml, Katja Lammens, Karl-Peter Hopfner
Published 2013-01-01

Molecular architecture and regulation of BCL10-MALT1 filaments

by Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche, Daniel Krappmann, Katja Lammens
Published 2018-10-01

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.

by Simon Runge, Konstantin M J Sparrer, Charlotte Lässig, Katharina Hembach, Alina Baum, Adolfo García-Sastre, Johannes Söding, Karl-Klaus Conzelmann, Karl-Peter Hopfner
Published 2014-04-01

Genome information processing by the INO80 chromatin remodeler positions nucleosomes

by Elisa Oberbeckmann, Nils Krietenstein, Vanessa Niebauer, Yingfei Wang, Kevin Schall, Manuela Moldt, Tobias Straub, Remo Rohs, Karl-Peter Hopfner, Philipp Korber, Sebastian Eustermann
Published 2021-05-01

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing

by Elisa Oberbeckmann, Vanessa Niebauer, Shinya Watanabe, Lucas Farnung, Manuela Moldt, Andrea Schmid, Patrick Cramer, Craig L. Peterson, Sebastian Eustermann, Karl-Peter Hopfner, Philipp Korber
Published 2021-05-01

Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain.

by Sebastian Fenn, Christian B Schiller, Julia J Griese, Harald Duerr, Sabine Imhof-Jung, Christian Gassner, Joerg Moelleken, Joerg Thomas Regula, Wolfgang Schaefer, Markus Thomas, Christian Klein, Karl-Peter Hopfner, Hubert Kettenberger
Published 2013-01-01

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.

by Hanna Janke, Friederike Pastore, Daniela Schumacher, Tobias Herold, Karl-Peter Hopfner, Stephanie Schneider, Wolfgang E Berdel, Thomas Büchner, Bernhard J Woermann, Marion Subklewe, Stefan K Bohlander, Wolfgang Hiddemann, Karsten Spiekermann, Harald Polzer
Published 2014-01-01

SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells

by Siret Tahk, Binje Vick, Björn Hiller, Saskia Schmitt, Anetta Marcinek, Enrico D. Perini, Alexandra Leutbecher, Christian Augsberger, Anna Reischer, Benjamin Tast, Andreas Humpe, Irmela Jeremias, Marion Subklewe, Nadja C. Fenn, Karl-Peter Hopfner
Published 2021-09-01

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

by Charlotte Lässig, Sarah Matheisl, Konstantin MJ Sparrer, Carina C de Oliveira Mann, Manuela Moldt, Jenish R Patel, Marion Goldeck, Gunther Hartmann, Adolfo García-Sastre, Veit Hornung, Karl-Klaus Conzelmann, Roland Beckmann, Karl-Peter Hopfner
Published 2015-11-01

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

by Charlotte Lässig, Sarah Matheisl, Konstantin MJ Sparrer, Carina C de Oliveira Mann, Manuela Moldt, Jenish R Patel, Marion Goldeck, Gunther Hartmann, Adolfo García-Sastre, Veit Hornung, Karl‐Klaus Conzelmann, Roland Beckmann, Karl-Peter Hopfner
Published 2016-03-01

Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural kille...

by Todd A. Braciak, Claudia C. Roskopf, Sarah Wildenhain, Nadja C. Fenn, Christian B. Schiller, Ingo A. Schubert, Uwe Jacob, Annemarie Honegger, Christina Krupka, Marion Subklewe, Karsten Spiekermann, Karl-Peter Hopfner, Georg H. Fey, Michael Aigner, Stefan Krause, Andreas Mackensen, Fuat S. Oduncu
Published 2018-09-01

Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activat...

by Saskia Schmitt, Siret Tahk, Alina Lohner, Alina Lohner, Gerulf Hänel, Gerulf Hänel, Andreas Maiser, Martina Hauke, Lubna Patel, Maurine Rothe, Maurine Rothe, Christine Josenhans, Christine Josenhans, Heinrich Leonhardt, Marieke Griffioen, Katrin Deiser, Katrin Deiser, Nadja C. Fenn, Karl-Peter Hopfner, Marion Subklewe, Marion Subklewe, Marion Subklewe
Published 2020-11-01

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation

by Luise Hartmann, Sayantanee Dutta, Sabrina Opatz, Sebastian Vosberg, Katrin Reiter, Georg Leubolt, Klaus H. Metzeler, Tobias Herold, Stefanos A. Bamopoulos, Kathrin Bräundl, Evelyn Zellmeier, Bianka Ksienzyk, Nikola P. Konstandin, Stephanie Schneider, Karl-Peter Hopfner, Alexander Graf, Stefan Krebs, Helmut Blum, Jan Moritz Middeke, Friedrich Stölzel, Christian Thiede, Stephan Wolf, Stefan K. Bohlander, Caroline Preiss, Linping Chen-Wichmann, Christian Wichmann, Maria Cristina Sauerland, Thomas Büchner, Wolfgang E. Berdel, Bernhard J. Wörmann, Jan Braess, Wolfgang Hiddemann, Karsten Spiekermann, Philipp A. Greif
Published 2016-06-01

Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

by Deepak Bararia, Johannes A. Hildebrand, Sebastian Stolz, Sarah Haebe, Stefan Alig, Christopher P. Trevisani, Francisco Osorio-Barrios, Michael D. Bartoschek, Michael Mentz, Alessandro Pastore, Erik Gaitzsch, Michael Heide, Vindi Jurinovic, Katharina Rautter, Jay Gunawardana, Muhammed B. Sabdia, Monika Szczepanowski, Julia Richter, Wolfram Klapper, Abner Louissaint, Jr., Christina Ludwig, Sebastian Bultmann, Heinrich Leonhardt, Sebastian Eustermann, Karl-Peter Hopfner, Wolfgang Hiddemann, Michael von Bergwelt-Baildon, Christian Steidl, Robert Kridel, Joshua W.D. Tobin, Maher K. Gandhi, David M. Weinstock, Marc Schmidt-Supprian, Menyhárt B. Sárosi, Martina Rudelius, Verena Passerini, Josef Mautner, Oliver Weigert
Published 2020-05-01