Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics

by Bianca Vora, Deanna J. Brackman, Ling Zou, Maria Garcia‐Cremades, Marina Sirota, Radojka M. Savic, Kathleen M. Giacomini
Published 2021-07-01

Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers

by Sook Wah Yee, Marilyn M. Giacomini, Hong Shen, W. Griffith Humphreys, Howard Horng, William Brian, Yurong Lai, Deanna L. Kroetz, Kathleen M. Giacomini
Published 2019-07-01

GenEpi: gene-based epistasis discovery using machine learning

by Yu-Chuan Chang, June-Tai Wu, Ming-Yi Hong, Yi-An Tung, Ping-Han Hsieh, Sook Wah Yee, Kathleen M. Giacomini, Yen-Jen Oyang, Chien-Yu Chen, for the Alzheimer’s Disease Neuroimaging Initiative
Published 2020-02-01

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.

by Xiaomin Liang, Sook Wah Yee, Huan-Chieh Chien, Eugene C Chen, Qi Luo, Ling Zou, Meiling Piao, Arias Mifune, Ligong Chen, Meredith E Calvert, Sarah King, Frode Norheim, Janna Abad, Ronald M Krauss, Kathleen M Giacomini
Published 2018-04-01

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

by Sook Wah Yee, Adrian Stecula, Huan-Chieh Chien, Ling Zou, Elena V Feofanova, Marjolein van Borselen, Kit Wun Kathy Cheung, Noha A Yousri, Karsten Suhre, Jason M Kinchen, Eric Boerwinkle, Roshanak Irannejad, Bing Yu, Kathleen M Giacomini
Published 2019-09-01

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.

by Wenxin Song, Qi Luo, Yuping Zhang, Linkang Zhou, Ye Liu, Zhilong Ma, Jianan Guo, Yuedong Huang, Lili Cheng, Ziyi Meng, Zicheng Li, Bin Zhang, Siqi Li, Sook Wah Yee, Hao Fan, Peng Li, Kathleen M Giacomini, Ligong Chen
Published 2019-01-01

Genomic Characterization of Metformin Hepatic Response.

by Marcelo R Luizon, Walter L Eckalbar, Yao Wang, Stacy L Jones, Robin P Smith, Megan Laurance, Lawrence Lin, Paul J Gallins, Amy S Etheridge, Fred Wright, Yihui Zhou, Cliona Molony, Federico Innocenti, Sook Wah Yee, Kathleen M Giacomini, Nadav Ahituv
Published 2016-11-01

Genome-wide discovery of drug-dependent human liver regulatory elements.

by Robin P Smith, Walter L Eckalbar, Kari M Morrissey, Marcelo R Luizon, Thomas J Hoffmann, Xuefeng Sun, Stacy L Jones, Shelley Force Aldred, Anuradha Ramamoorthy, Zeruesenay Desta, Yunlong Liu, Todd C Skaar, Nathan D Trinklein, Kathleen M Giacomini, Nadav Ahituv
Published 2014-10-01

Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.

by Stephanie E Hesselson, Pär Matsson, James E Shima, Hisayo Fukushima, Sook Wah Yee, Yuya Kobayashi, Jason M Gow, Connie Ha, Benjamin Ma, Annie Poon, Susan J Johns, Doug Stryke, Richard A Castro, Harunobu Tahara, Ji Ha Choi, Ligong Chen, Nicolas Picard, Elin Sjödin, Maarke J E Roelofs, Thomas E Ferrin, Richard Myers, Deanna L Kroetz, Pui-Yan Kwok, Kathleen M Giacomini
Published 2009-09-01