Morphological Change by Overexpression of D385A Dominant Negative Presenilin 1 in Human Neuroblastoma SH-SY5Y Cells

by Daiju Tsuchiya, Yoshihisa Kitamura, Kazuyuki Takata, Takashi Taniguchi, Kengo Uemura, Hiroaki Miki, Tadaomi Takenawa, Shun Shimohama
Published 2006-01-01

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

by Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M. Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T. Hyman, Oksana Berezovska
Published 2013-02-01

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

by Kengo Uemura, Christina M Lill, Xuejing Li, Jessica A Peters, Alexander Ivanov, Zhanyun Fan, Bart DeStrooper, Brian J Bacskai, Bradley T Hyman, Oksana Berezovska
Published 2009-11-01

Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.

by Masato Maesako, Kengo Uemura, Ayana Iwata, Masakazu Kubota, Kiwamu Watanabe, Maiko Uemura, Yasuha Noda, Megumi Asada-Utsugi, Takeshi Kihara, Ryosuke Takahashi, Shun Shimohama, Ayae Kinoshita
Published 2013-01-01

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

by Yasuha Noda, Akira Kuzuya, Kyousuke Tanigawa, Mitsugu Araki, Ryoko Kawai, Biao Ma, Yoko Sasakura, Masato Maesako, Yoshitaka Tashiro, Masakazu Miyamoto, Kengo Uemura, Yasushi Okuno, Ayae Kinoshita
Published 2018-10-01

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

by Masato Maesako, Maiko Uemura, Yoshitaka Tashiro, Kazuki Sasaki, Kiwamu Watanabe, Yasuha Noda, Karin Ueda, Megumi Asada-Utsugi, Masakazu Kubota, Katsuya Okawa, Masafumi Ihara, Shun Shimohama, Kengo Uemura, Ayae Kinoshita
Published 2015-01-01

The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.

by Yuzuru Imai, Yoshito Kobayashi, Tsuyoshi Inoshita, Hongrui Meng, Taku Arano, Kengo Uemura, Takeshi Asano, Kenji Yoshimi, Chang-Liang Zhang, Gen Matsumoto, Toshiyuki Ohtsuka, Ryoichiro Kageyama, Hiroshi Kiyonari, Go Shioi, Nobuyuki Nukina, Nobutaka Hattori, Ryosuke Takahashi
Published 2015-09-01