A Physiologically‐Based Pharmacokinetic Model for the Prediction of “Half‐Life Extension” and “Catch and Release” Monoclonal Antibody Pharmacokinetics

by Hannah M. Jones, John Tolsma, Zhiwei Zhang, Paul Jasper, Haobin Luo, Gregory L. Weber, Katherine Wright, Joel Bard, Robert Bell, Dean Messing, Kerry Kelleher, Nicole Piche‐Nicholas, Robert Webster
Published 2020-09-01

Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design.

by James R Apgar, Amy S P Tam, Rhady Sorm, Sybille Moesta, Amy C King, Han Yang, Kerry Kelleher, Denise Murphy, Aaron M D'Antona, Guoying Yan, Xiaotian Zhong, Linette Rodriguez, Weijun Ma, Darren E Ferguson, Gregory J Carven, Eric M Bennett, Laura Lin
Published 2020-01-01

Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation

by Danna M. Breen, Srinath Jagarlapudi, Anita Patel, Chang Zou, Stephanie Joaquim, Xiangping Li, Liya Kang, Jincheng Pang, Katherine Hales, Enida Ziso-Qejvanaj, Nicholas B. Vera, Donald Bennett, Tao He, Matthew Lambert, Kerry Kelleher, Zhidan Wu, Bei B. Zhang, Laura Lin, Randy J. Seeley, Olivier Bezy
Published 2021-06-01

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

by Ella Fung, Liya Kang, Diana Sapashnik, Susan Benard, Annette Sievers, Yan Liu, Guoying Yan, Jing Zhou, Linette Rodriguez, Weijun Ma, Wayne R. Stochaj, Edward LaVallie, Liliana Wroblewska, Kerry Kelleher, Amy Tam, Olivier Bezy, Danna Breen, Jeffrey R. Chabot, Tao He, Laura Lin, Zhidan Wu, Lidia Mosyak
Published 2021-04-01