Nanog-Independent Reprogramming to iPSCs with Canonical Factors

by Ava C. Carter, Brandi N. Davis-Dusenbery, Kathryn Koszka, Justin K. Ichida, Kevin Eggan
Published 2014-02-01

Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9

by Amanda Herring, Angelica Messana, Anne M. Bara, Dane Z. Hazelbaker, Kevin Eggan, Lindy E. Barrett
Published 2016-09-01

Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9

by Anne M. Bara, Angelica Messana, Amanda Herring, Dane Z. Hazelbaker, Kevin Eggan, Lindy E. Barrett
Published 2016-09-01

Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons

by Jiro Kawada, Shohei Kaneda, Takaaki Kirihara, Asif Maroof, Timothée Levi, Kevin Eggan, Teruo Fujii, Yoshiho Ikeuchi
Published 2017-11-01

Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus

by Florian T. Merkle, Werner M. Neuhausser, David Santos, Eivind Valen, James A. Gagnon, Kristi Maas, Jackson Sandoe, Alexander F. Schier, Kevin Eggan
Published 2015-05-01

A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease

by Dane Z. Hazelbaker, Amanda Beccard, Anne M. Bara, Nicole Dabkowski, Angelica Messana, Patrizia Mazzucato, Daisy Lam, Danielle Manning, Kevin Eggan, Lindy E. Barrett
Published 2017-10-01

Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications

by Peter W. Andrews, Uri Ben-David, Nissim Benvenisty, Peter Coffey, Kevin Eggan, Barbara B. Knowles, Andras Nagy, Martin Pera, Benjamin Reubinoff, Peter J. Rugg-Gunn, Glyn N. Stacey
Published 2017-07-01

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients

by Daniel A. Mordes, Mercedes Prudencio, Lindsey D. Goodman, Joseph R. Klim, Rob Moccia, Francesco Limone, Olli Pietilainen, Kaitavjeet Chowdhary, Dennis W. Dickson, Rosa Rademakers, Nancy M. Bonini, Leonard Petrucelli, Kevin Eggan
Published 2018-07-01

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

by Pratibha Tripathi, Natalia Rodriguez-Muela, Joseph R. Klim, A. Sophie de Boer, Sahil Agrawal, Jackson Sandoe, Claudia S. Lopes, Karolyn Sassi Ogliari, Luis A. Williams, Matthew Shear, Lee L. Rubin, Kevin Eggan, Qiao Zhou
Published 2017-08-01

A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport

by Evgeny Shlevkov, Himanish Basu, Mark-Anthony Bray, Zheng Sun, Wei Wei, Kaan Apaydin, Kyle Karhohs, Pin-Fang Chen, Janell L.M. Smith, Ole Wiskow, Kasper Roet, Xuan Huang, Kevin Eggan, Anne E. Carpenter, Robin J. Kleiman, Thomas L. Schwarz
Published 2019-09-01

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

by Brian J. Wainger, Evangelos Kiskinis, Cassidy Mellin, Ole Wiskow, Steve S.W. Han, Jackson Sandoe, Numa P. Perez, Luis A. Williams, Seungkyu Lee, Gabriella Boulting, James D. Berry, Robert H. Brown Jr., Merit E. Cudkowicz, Bruce P. Bean, Kevin Eggan, Clifford J. Woolf
Published 2014-04-01

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

by Ralda Nehme, Emanuela Zuccaro, Sulagna Dia Ghosh, Chenchen Li, John L. Sherwood, Olli Pietilainen, Lindy E. Barrett, Francesco Limone, Kathleen A. Worringer, Sravya Kommineni, Ying Zang, Davide Cacchiarelli, Alex Meissner, Rolf Adolfsson, Stephen Haggarty, Jon Madison, Matthias Muller, Paola Arlotta, Zhanyan Fu, Guoping Feng, Kevin Eggan
Published 2018-05-01

Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging

by Feng Tian, Wenlong Yang, Daniel A. Mordes, Jin-Yuan Wang, Johnny S. Salameh, Joanie Mok, Jeannie Chew, Aarti Sharma, Ester Leno-Duran, Satomi Suzuki-Uematsu, Naoki Suzuki, Steve S. Han, Fa-Ke Lu, Minbiao Ji, Rosanna Zhang, Yue Liu, Jack Strominger, Neil A. Shneider, Leonard Petrucelli, X. Sunney Xie, Kevin Eggan
Published 2016-10-01

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease

by Chris M. Woodard, Brian A. Campos, Sheng-Han Kuo, Melissa J. Nirenberg, Michael W. Nestor, Matthew Zimmer, Eugene V. Mosharov, David Sulzer, Hongyan Zhou, Daniel Paull, Lorraine Clark, Eric E. Schadt, Sergio Pablo Sardi, Lee Rubin, Kevin Eggan, Mathew Brock, Scott Lipnick, Mahendra Rao, Stephen Chang, Aiqun Li, Scott A. Noggle
Published 2014-11-01