The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease.

by John S Bett, Casey Cook, Leonard Petrucelli, Gillian P Bates
Published 2009-01-01

Cellular and pathological heterogeneity of primary tauopathies

by Dah-eun Chloe Chung, Shanu Roemer, Leonard Petrucelli, Dennis W. Dickson
Published 2021-08-01

Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.

by Simon D'Alton, Marcelle Altshuler, Ashley Cannon, Dennis W Dickson, Leonard Petrucelli, Jada Lewis
Published 2014-01-01

TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.

by Alexandra Vaccaro, Arnaud Tauffenberger, Peter E A Ash, Yari Carlomagno, Leonard Petrucelli, J Alex Parker
Published 2012-07-01

Three repeat isoforms of tau inhibit assembly of four repeat tau filaments.

by Stephanie J Adams, Michael A DeTure, Melinda McBride, Dennis W Dickson, Leonard Petrucelli
Published 2010-05-01

C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation

by Keith A. Josephs, Yong-Jie Zhang, Matthew Baker, Rosa Rademakers, Leonard Petrucelli, Dennis W. Dickson
Published 2019-07-01

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

by Lindsey D. Goodman, Mercedes Prudencio, Ananth R. Srinivasan, Olivia M. Rifai, Virginia M.-Y. Lee, Leonard Petrucelli, Nancy M. Bonini
Published 2019-04-01

Aging is not associated with proteasome impairment in UPS reporter mice.

by Casey Cook, Jennifer Gass, Judith Dunmore, Jimei Tong, Julie Taylor, Jason Eriksen, Eileen McGowan, Jada Lewis, Jennifer Johnston, Leonard Petrucelli
Published 2009-06-01

Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease

by Nobutaka Sakae, Kevin F. Bieniek, Yong-Jie Zhang, Kelly Ross, Tania F. Gendron, Melissa E. Murray, Rosa Rademakers, Leonard Petrucelli, Dennis W. Dickson
Published 2018-07-01

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

by Hibiki Kawamata, Pablo Peixoto, Csaba Konrad, Gloria Palomo, Kirsten Bredvik, Meri Gerges, Federica Valsecchi, Leonard Petrucelli, John M. Ravits, Anatoly Starkov, Giovanni Manfredi
Published 2017-05-01

Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins.

by Yari Carlomagno, Yongjie Zhang, Mary Davis, Wen-Lang Lin, Casey Cook, Judy Dunmore, William Tay, Kyle Menkosky, Xiangkun Cao, Leonard Petrucelli, Michael Deture
Published 2014-01-01

Correction: Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

by Liqun Liu-Yesucevitz, Aylin Bilgutay, Yong-Jie Zhang, Tara Vanderweyde, Allison Citro, Tapan Mehta, Nava Zaarur, Ann McKee, Robert Bowser, Michael Sherman, Leonard Petrucelli, Benjamin Wolozin
Published 2011-01-01

Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue.

by Liqun Liu-Yesucevitz, Aylin Bilgutay, Yong-Jie Zhang, Tara Vanderweyde, Allison Citro, Tapan Mehta, Nava Zaarur, Ann McKee, Robert Bowser, Michael Sherman, Leonard Petrucelli, Benjamin Wolozin
Published 2010-10-01

Correction: Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue.

by Liqun Liu-Yesucevitz, Aylin Bilgutay, Yong-Jie Zhang, Tara Vanderweyde, Allison Citro, Tapan Mehta, Nava Zaarur, Ann McKee, Robert Bowser, Michael Sherman, Leonard Petrucelli, Benjamin Wolozin
Published 2011-01-01

Tau exhibits unique seeding properties in globular glial tauopathy

by Dah-eun Chloe Chung, Yari Carlomagno, Casey N. Cook, Karen Jansen-West, Lillian Daughrity, Laura J. Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W. Dickson, Leonard Petrucelli
Published 2019-03-01

Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations

by Nobutaka Sakae, Shanu F. Roemer, Kevin F. Bieniek, Melissa E. Murray, Matthew C. Baker, Koji Kasanuki, Neill R. Graff‐Radford, Leonard Petrucelli, Marka Van Blitterswijk, Rosa Rademakers, Dennis W. Dickson
Published 2019-09-01

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients

by Daniel A. Mordes, Mercedes Prudencio, Lindsey D. Goodman, Joseph R. Klim, Rob Moccia, Francesco Limone, Olli Pietilainen, Kaitavjeet Chowdhary, Dennis W. Dickson, Rosa Rademakers, Nancy M. Bonini, Leonard Petrucelli, Kevin Eggan
Published 2018-07-01

The lysosomal protein cathepsin L is a progranulin protease

by Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, Leonard Petrucelli
Published 2017-07-01

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts

by Ricardos Tabet, Laure Schaeffer, Fernande Freyermuth, Melanie Jambeau, Michael Workman, Chao-Zong Lee, Chun-Chia Lin, Jie Jiang, Karen Jansen-West, Hussein Abou-Hamdan, Laurent Désaubry, Tania Gendron, Leonard Petrucelli, Franck Martin, Clotilde Lagier-Tourenne
Published 2018-01-01

Astrocyte-derived clusterin suppresses amyloid formation in vivo

by Aleksandra M. Wojtas, Jonathon P. Sens, Silvia S. Kang, Kelsey E. Baker, Taylor J. Berry, Aishe Kurti, Lillian Daughrity, Karen R. Jansen-West, Dennis W. Dickson, Leonard Petrucelli, Guojun Bu, Chia-Chen Liu, John D. Fryer
Published 2020-11-01