Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis.

by Panagiotis Papatheodorou, Constantinos Zamboglou, Selda Genisyuerek, Gregor Guttenberg, Klaus Aktories
Published 2010-05-01

Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT

by Michael Korbmacher, Stephan Fischer, Marc Landenberger, Panagiotis Papatheodorou, Klaus Aktories, Holger Barth
Published 2020-08-01

Correction: Lu/BCAM Adhesion Glycoprotein Is a Receptor for Cytotoxic Necrotizing Factor 1 (CNF1).

by Marianne Piteau, Panagiotis Papatheodorou, Carsten Schwan, Andreas Schlosser, Klaus Aktories, Gudula Schmidt
Published 2014-01-01

Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication

by Stefan Carle, Thorsten Brink, Joachim H. C. Orth, Klaus Aktories, Holger Barth
Published 2017-01-01

Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1).

by Marianne Piteau, Panagiotis Papatheodorou, Carsten Schwan, Andreas Schlosser, Klaus Aktories, Gudula Schmidt
Published 2014-01-01

Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.

by Claudia Antoni, Dennis Quentin, Alexander E Lang, Klaus Aktories, Christos Gatsogiannis, Stefan Raunser
Published 2020-08-01

Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin.

by Alexander Belyy, Irina Tabakova, Alexander E Lang, Thomas Jank, Yury Belyi, Klaus Aktories
Published 2015-01-01

Involvement of Osteocytes in the Action of Pasteurella multocida Toxin

by Hannah Heni, Julia K. Ebner, Gudula Schmidt, Klaus Aktories, Joachim H. C. Orth
Published 2018-08-01

Tailored Cyclodextrin Pore Blocker Protects Mammalian Cells from Clostridium difficile Binary Toxin CDT

by Maurice Roeder, Ekaterina M. Nestorovich, Vladimir A. Karginov, Carsten Schwan, Klaus Aktories, Holger Barth
Published 2014-07-01

Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis.

by Peter Siegert, Gudula Schmidt, Panagiotis Papatheodorou, Thomas Wieland, Klaus Aktories, Joachim H C Orth
Published 2013-01-01

Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria.

by Carsten Schwan, Bärbel Stecher, Tina Tzivelekidis, Marco van Ham, Manfred Rohde, Wolf-Dietrich Hardt, Jürgen Wehland, Klaus Aktories
Published 2009-10-01

Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) Induces Apoptosis in LNCaP Prostate Cancer Cells

by Anke Augspach, Joachim H. List, Philipp Wolf, Heike Bielek, Carsten Schwan, Ursula Elsässer-Beile, Klaus Aktories, Gudula Schmidt
Published 2013-11-01

Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases.

by Tina Tzivelekidis, Thomas Jank, Corinna Pohl, Andreas Schlosser, Sabine Rospert, Charlotte R Knudsen, Marina V Rodnina, Yury Belyi, Klaus Aktories
Published 2011-01-01

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin

by Leonie Schnell, Ann-Katrin Mittler, Mirko Sadi, Michel R. Popoff, Carsten Schwan, Klaus Aktories, Andrea Mattarei, Domenico Azarnia Tehran, Cesare Montecucco, Holger Barth
Published 2016-04-01

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins.

by Thorsten Brink, Veronika Leiss, Peter Siegert, Doris Jehle, Julia K Ebner, Carsten Schwan, Aliaksei Shymanets, Sebastian Wiese, Bernd Nürnberg, Michael Hensel, Klaus Aktories, Joachim H C Orth
Published 2018-08-01

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

by Manuel Schuster, Leonie Schnell, Peter Feigl, Carina Birkhofer, Katharina Mohr, Maurice Roeder, Stefan Carle, Simon Langer, Franziska Tippel, Johannes Buchner, Gunter Fischer, Felix Hausch, Manfred Frick, Carsten Schwan, Klaus Aktories, Cordelia Schiene-Fischer, Holger Barth
Published 2017-04-01

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

by Florian Haun, Simon Neumann, Lukas Peintner, Katrin Wieland, Jüri Habicht, Carsten Schwan, Kristine Østevold, Maria Magdalena Koczorowska, Martin Biniossek, Matthias Kist, Hauke Busch, Melanie Boerries, Roger J. Davis, Ulrich Maurer, Oliver Schilling, Klaus Aktories, Christoph Borner
Published 2018-08-01

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells

by Katharina Ernst, Johannes Schmid, Matthias Beck, Marlen Hägele, Meike Hohwieler, Patricia Hauff, Anna Katharina Ückert, Anna Anastasia, Michael Fauler, Thomas Jank, Klaus Aktories, Michel R. Popoff, Cordelia Schiene-Fischer, Alexander Kleger, Martin Müller, Manfred Frick, Holger Barth
Published 2017-06-01