Subversion of inflammasome activation and pyroptosis by pathogenic bacteria

by Larissa D Cunha, Dario S Zamboni
Published 2013-11-01

The use of a heterogeneously controlled mouse population reveals a significant correlation of acute phase parasitemia with mortality in Chagas disease.

by Tiago L M Sanches, Larissa D Cunha, Grace K Silva, Paulo M M Guedes, João Santana Silva, Dario S Zamboni
Published 2014-01-01

A parent-of-origin effect determines the susceptibility of a non-informative F1 population to Trypanosoma cruzi infection in vivo.

by Grace K Silva, Larissa D Cunha, Catarina V Horta, Alexandre L N Silva, Fredy R S Gutierrez, João S Silva, Dario S Zamboni
Published 2013-01-01

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome.

by Danielle P A Mascarenhas, Daiane M Cerqueira, Marcelo S F Pereira, Fernanda V S Castanheira, Talita D Fernandes, Graziele Z Manin, Larissa D Cunha, Dario S Zamboni
Published 2017-08-01

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome

by Larissa D. Cunha, Alexandre L.N. Silva, Juliana M. Ribeiro, Danielle P.A. Mascarenhas, Gustavo F.S. Quirino, Leonardo L. Santos, Richard A. Flavell, Dario S. Zamboni
Published 2017-07-01

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response.

by Fabiane Sônego, Fernanda V S Castanheira, Paula G Czaikoski, Alexandre Kanashiro, Fabricio O Souto, Rafael O França, Daniele C Nascimento, Andressa Freitas, Fernando Spiller, Larissa D Cunha, Dario S Zamboni, José C Alves-Filho, Fernando Q Cunha
Published 2014-01-01

Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial

by Maria Isabel Lopes, Leticia P Bonjorno, Marcela C Giannini, Natalia B Amaral, Pamella Indira Menezes, Saulo Musse Dib, Samara Libich Gigante, Maira N Benatti, Uebe C Rezek, Laerte L Emrich-Filho, Betania A A Sousa, Sergio C L Almeida, Rodrigo Luppino Assad, Flavio P Veras, Ayda Schneider, Tamara S Rodrigues, Luiz O S Leiria, Larissa D Cunha, Jose C Alves-Filho, Thiago M Cunha, Eurico Arruda, Carlos H Miranda, Antonio Pazin-Filho, Maria Auxiliadora-Martins, Marcos C Borges, Benedito A L Fonseca, Valdes R Bollela, Cristina M Del-Ben, Fernando Q Cunha, Dario S Zamboni, Rodrigo C Santana, Fernando C Vilar, Paulo Louzada-Junior, Rene D R Oliveira
Published 2021-04-01