Data on the mechanisms underlying succinate-induced aortic contraction

by Natália A. Gonzaga, Janaina A. Simplicio, Letícia N. Leite, Gabriel T. Vale, José M. Carballido, José C. Alves-Filho, Carlos R. Tirapelli
Published 2016-12-01

Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw.

by Igor L Calil, Ana C Zarpelon, Ana T G Guerrero, Jose C Alves-Filho, Sergio H Ferreira, Fernando Q Cunha, Thiago M Cunha, Waldiceu A Verri
Published 2014-01-01

Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury.

by Cristiana C Garcia, Wynne Weston-Davies, Remo C Russo, Luciana P Tavares, Milene A Rachid, José C Alves-Filho, Alexandre V Machado, Bernhard Ryffel, Miles A Nunn, Mauro M Teixeira
Published 2013-01-01

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response.

by Fabiane Sônego, Fernanda V S Castanheira, Paula G Czaikoski, Alexandre Kanashiro, Fabricio O Souto, Rafael O França, Daniele C Nascimento, Andressa Freitas, Fernando Spiller, Larissa D Cunha, Dario S Zamboni, José C Alves-Filho, Fernando Q Cunha
Published 2014-01-01

Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice

by Victor Fattori, Ana C. Zarpelon, Larissa Staurengo-Ferrari, Sergio M. Borghi, Tiago H. Zaninelli, Fernando B. Da Costa, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Nilton S. Arakawa, Waldiceu A. Verri
Published 2018-09-01

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

by Yuri Lourenco-Gonzalez, Victor Fattori, Talita P. Domiciano, Ana C. Rossaneis, Sergio M. Borghi, Tiago H. Zaninelli, Catia C. F. Bernardy, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri
Published 2019-01-01

IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10

by Miriam M. Fonseca, Marcela Davoli-Ferreira, Marcela Davoli-Ferreira, Flávia Santa-Cecília, Rafaela M. Guimarães, Rafaela M. Guimarães, Francisco F. B. Oliveira, Ricardo Kusuda, David W. Ferreira, José C. Alves-Filho, Fernando Q. Cunha, Thiago M. Cunha
Published 2020-01-01

Paradoxical roles of the neutrophil in sepsis: protective and deleterious

by Fabiane eSônego, Fabiane eSônego, Fernanda Vargas e Silva Castanheira, Raphael Gomes Ferreira, Alexandre eKanashiro, Caio Abner Vitorino Golçalves Leite, Daniele Carvalho Nascimento, David Fernando Colón, Vanessa Fátima Borges, José C Alves-Filho, Fernando Queiróz Cunha
Published 2016-04-01

5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality

by Miriam S. N. Hohmann, Renato D. R. Cardoso, Felipe A. Pinho-Ribeiro, Jefferson Crespigio, Thiago M. Cunha, José C. Alves-Filho, Rosiane V. da Silva, Phileno Pinge-Filho, Sergio H. Ferreira, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri
Published 2013-01-01

Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells

by Jhimmy Talbot, Raphael S. Peres, Larissa G. Pinto, Rene D. R. Oliveira, Kalil A. Lima, Paula B. Donate, Jaqueline R. Silva, Bernard Ryffel, Thiago M. Cunha, José C. Alves-Filho, Foo Y. Liew, Paulo Louzada-Junior, Fernando de Queiroz Cunha
Published 2018-06-01

Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

by Larissa Staurengo-Ferrari, Kenji W. Ruiz-Miyazawa, Felipe A. Pinho-Ribeiro, Victor Fattori, Tiago H. Zaninelli, Stephanie Badaro-Garcia, Sergio M. Borghi, Thacyana T. Carvalho, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri
Published 2018-10-01

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

by Kenji W. Ruiz-Miyazawa, Sergio M. Borghi, Felipe A. Pinho-Ribeiro, Larissa Staurengo-Ferrari, Victor Fattori, Glaura S.A. Fernandes, Antonio M. Casella, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri, Jr
Published 2018-09-01

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice

by Sergio M. Borghi, Victor Fattori, Felipe A. Pinho-Ribeiro, Talita P. Domiciano, Milena M. Miranda-Sapla, Tiago H. Zaninelli, Rubia Casagrande, Phileno Pinge-Filho, Wander R. Pavanelli, Jose C. Alves-Filho, Fernando Q. Cunha, Thiago M. Cunha, Waldiceu A. Verri
Published 2019-05-01

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

by Daniele C. Nascimento, Paulo H. Melo, Annie R. Piñeros, Raphael G. Ferreira, David F. Colón, Paula B. Donate, Fernanda V. Castanheira, Aline Gozzi, Paula G. Czaikoski, Wanda Niedbala, Marcos C. Borges, Dario S. Zamboni, Foo Y. Liew, Fernando Q. Cunha, Jose C. Alves-Filho
Published 2017-04-01

IL-22 Promotes IFN-γ-Mediated Immunity against <i>Histoplasma capsulatum</i> Infection

by Morgana K.B. Prado, Caroline Fontanari, Camila O.S. Souza, Luiz G. Gardinassi, Karina F. Zoccal, Francisco W.G. de Paula-Silva, Ana P.F. Peti, Carlos A. Sorgi, Alyne F.G. Meirelles, Simone G. Ramos, José C. Alves-Filho, Lúcia H. Faccioli
Published 2020-06-01

Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis

by Fernanda S. Soares, Flávia C. Amaral, Natália L. C. Silva, Matheus R. Valente, Lorena K. R. Santos, Lívia H. Yamashiro, Mara C. Scheffer, Fernanda V. E. S. Castanheira, Raphael G. Ferreira, Laura Gehrke, José C. Alves-Filho, Luciano P. Silva, Luciano P. Silva, André Báfica, André Báfica, Fernando Spiller, Fernando Spiller
Published 2017-12-01

Molecular basis of carrageenan-induced cytokines production in macrophages

by Alexandre H. Lopes, Rangel L. Silva, Miriam D. Fonseca, Francisco I. Gomes, Alexandre G. Maganin, Lucas S. Ribeiro, Lucas Maciel Mauriz Marques, Fernando Q. Cunha, Jose C. Alves-Filho, Dario S. Zamboni, Norberto P. Lopes, Bernardo S. Franklin, Aurélie Gombault, Fernando Silva Ramalho, Valerie F. J. Quesniaux, Isabelle Couillin, Bernhard Ryffel, Thiago M. Cunha
Published 2020-09-01

Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis

by David F. Colón, Carlos W. Wanderley, Marcelo Franchin, Camila M. Silva, Carlos H. Hiroki, Fernanda V. S. Castanheira, Paula B. Donate, Alexandre H. Lopes, Leila C. Volpon, Silvia K. Kavaguti, Vanessa F. Borges, Cesar A. Speck-Hernandez, Fernando Ramalho, Ana P. Carlotti, Fabio Carmona, Jose C. Alves-Filho, Foo Y. Liew, Fernando Q. Cunha
Published 2019-04-01

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis

by Larissa Staurengo-Ferrari, Silvia C. Trevelin, Silvia C. Trevelin, Victor Fattori, Daniele C. Nascimento, Kalil A. de Lima, Jacinta S. Pelayo, Florêncio Figueiredo, Rubia Casagrande, Sandra Y. Fukada, Mauro M. Teixeira, Thiago M. Cunha, Foo Y. Liew, Rene D. Oliveira, Paulo Louzada-Junior, Fernando Q. Cunha, José C. Alves-Filho, Waldiceu A. Verri
Published 2018-05-01

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

by Maria C. Silva, Marcela Davoli-Ferreira, Tiago S. Medina, Renata Sesti-Costa, Grace K. Silva, Carla D. Lopes, Lucas E. Cardozo, Fábio N. Gava, Konstantina Lyroni, Fabrício C. Dias, Amanda F. Frade, Monique Baron, Helder I. Nakaya, Florêncio Figueiredo, José C. Alves-Filho, Fernando Q. Cunha, Christos Tsatsanis, Christophe Chevillard, Edecio Cunha-Neto, Emilio Hirsch, João S. Silva, Thiago M. Cunha
Published 2018-04-01