The Surprising Role of Amyloid Fibrils in HIV Infection

by James Shorter, Laura M. Castellano
Published 2012-05-01

Suramin inhibits Hsp104 ATPase and disaggregase activity.

by Mariana P Torrente, Laura M Castellano, James Shorter
Published 2014-01-01

Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils

by Laura M. Castellano, Rebecca M. Hammond, Veronica M. Holmes, Drew Weissman, James Shorter
Published 2015-09-01

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase

by Alexandrea N. Rizo, JiaBei Lin, Stephanie N. Gates, Eric Tse, Stephen M. Bart, Laura M. Castellano, Frank DiMaio, James Shorter, Daniel R. Southworth
Published 2019-06-01

Therapeutic genetic variation revealed in diverse Hsp104 homologs

by Zachary M March, Katelyn Sweeney, Hanna Kim, Xiaohui Yan, Laura M Castellano, Meredith E Jackrel, JiaBei Lin, Edward Chuang, Edward Gomes, Corey W Willicott, Karolina Michalska, Robert P Jedrzejczak, Andrzej Joachimiak, Kim A Caldwell, Guy A Caldwell, Ophir Shalem, James Shorter
Published 2020-12-01

A molecular tweezer antagonizes seminal amyloids and HIV infection

by Edina Lump, Laura M Castellano, Christoph Meier, Janine Seeliger, Nelli Erwin, Benjamin Sperlich, Christina M Stürzel, Shariq Usmani, Rebecca M Hammond, Jens von Einem, Gisa Gerold, Florian Kreppel, Kenny Bravo-Rodriguez, Thomas Pietschmann, Veronica M Holmes, David Palesch, Onofrio Zirafi, Drew Weissman, Andrea Sowislok, Burkhard Wettig, Christian Heid, Frank Kirchhoff, Tanja Weil, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Elsa Sanchez-Garcia, Roland Winter, James Shorter, Jan Münch
Published 2015-08-01